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Assay Detail

CHEMBL4619676

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Functional
Inhibition of colony formation in human BE(2)-C cells
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Homo sapiens
Cell Type BE(2)-C
Confidence 1 — Organism
Curated By Autocuration

Target

BE(2)-C (CHEMBL4483229)
Type CELL-LINE
Organism Homo sapiens

Publication

Characterization of Conformationally Constrained Benzanilide Scaffolds for Potent and Selective HDAC8 Targeting.
Hassan MM, Israelian J, Nawar N, Ganda G, Manaswiyoungkul P, Raouf YS, Armstrong D, Sedighi A, Olaoye OO, Erdogan F, Cabral AD, Angeles F, Altintas R, de Araujo ED, Gunning PT.
J Med Chem (2020) 63 : 8634 -8648
PubMed 32672458 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 2 5.60 5.68

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL4637798 1 5.68
CHEMBL2170177 1 5.51

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL4637798 IC50 = 2100.0 nM 5.68
CHEMBL2170177 IC50 = 3100.0 nM 5.51