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Assay Detail

CHEMBL4619829

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Functional
Antiproliferative activity against human MCF7 cells assessed as cell growth inhibition
20
Total Activities
20
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Homo sapiens
Cell Type MCF7
Confidence 1 — Organism
Curated By Autocuration

Target

MCF7 (CHEMBL387)
Type CELL-LINE
Organism Homo sapiens

Publication

Neutral analogs of the heat shock protein 70 (Hsp70) inhibitor, JG-98.
Shao H, Gestwicki JE.
Bioorg Med Chem Lett (2020) 30 : 126954 -126954
PubMed 31952963 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 20 6.06 7.00

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL4637547 1 7.00
CHEMBL4645671 1 6.89
CHEMBL4639416 1 6.64
CHEMBL4634734 1 6.48
CHEMBL4645949 1 6.40
CHEMBL4635971 1 6.38
CHEMBL4637513 1 6.19
CHEMBL4648538 1 6.15
CHEMBL4640077 1 6.15
CHEMBL3091939 1 6.15
CHEMBL4647280 1 6.12
CHEMBL4634735 1 6.00
CHEMBL4646887 1 5.92
CHEMBL4638813 1 5.89
CHEMBL4634602 1 5.89
CHEMBL4647237 1 5.82
CHEMBL4648041 1 5.77
CHEMBL4633022 1 5.44
CHEMBL4636034 1 5.12
CHEMBL4647441 1 4.89

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL4637547 IC50 = 100.0 nM 7.00
CHEMBL4645671 IC50 = 130.0 nM 6.89
CHEMBL4639416 IC50 = 230.0 nM 6.64
CHEMBL4634734 IC50 = 330.0 nM 6.48
CHEMBL4645949 IC50 = 400.0 nM 6.40
CHEMBL4635971 IC50 = 420.0 nM 6.38
CHEMBL4637513 IC50 = 650.0 nM 6.19
CHEMBL4648538 IC50 = 710.0 nM 6.15
CHEMBL4640077 IC50 = 710.0 nM 6.15
CHEMBL3091939 IC50 = 710.0 nM 6.15
CHEMBL4647280 IC50 = 750.0 nM 6.12
CHEMBL4634735 IC50 = 990.0 nM 6.00
CHEMBL4646887 IC50 = 1200.0 nM 5.92
CHEMBL4638813 IC50 = 1300.0 nM 5.89
CHEMBL4634602 IC50 = 1300.0 nM 5.89
CHEMBL4647237 IC50 = 1500.0 nM 5.82
CHEMBL4648041 IC50 = 1700.0 nM 5.77
CHEMBL4633022 IC50 = 3600.0 nM 5.44
CHEMBL4636034 IC50 = 7600.0 nM 5.12
CHEMBL4647441 IC50 = 13000.0 nM 4.89