Assay Detail

CHEMBL4619847

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Binding

Allosteric inhibition of Flavivirus NS2B-NS3 protease

ChEMBL ↗

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Target

Unchecked (CHEMBL612545) ↗

Open DB target context

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Primary target Unchecked

CHEMBL612545

Anchored from Assay target.

Protein identity Unchecked

Disease frame Disease evidence pending

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Review focus Open DB context pending

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Total Activities

Compounds Tested

Activity Types

Assay Parameters

Assay Information

Assay Type	Binding
Organism	Flavivirus
Confidence	0 — Uncurated / Unknown
Curated By	Autocuration

Target

Unchecked (CHEMBL612545) ↗

Type

UNCHECKED

Publication

Inhibitors of the Zika virus protease NS2B-NS3.

Voss S, Nitsche C.
Bioorg Med Chem Lett (2020) 30 : 126965 -126965
PubMed 31980339 · DOI

Activity Statistics

Type	Count	Avg pChEMBL	Best pChEMBL
IC50	2	6.56	6.70

Compounds Tested

Compound	Name	Phase	Activities	Best pChEMBL
CHEMBL3039522	BIRINAPANT	2.0	1	6.70
CHEMBL3600721	—	—	1	6.42

Activity Data

Compound	Name	Type	Rel.	Value	Units	pChEMBL
CHEMBL3039522	BIRINAPANT	IC50	=	200.0	nM	6.70
CHEMBL3600721	—	IC50	=	380.0	nM	6.42