Assay Detail
Binding
CHEMBL4619931
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Agonist activity at D2 receptor (unknown origin)
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Synthesis and biological investigation of triazolopyridinone derivatives as potential multireceptor atypical antipsychotics.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 7 | 7.88 | 8.20 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2105760 | BREXPIPRAZOLE | 4.0 | 1 | 8.20 |
| CHEMBL4638599 | — | — | 1 | 7.87 |
| CHEMBL4644391 | — | — | 1 | 7.56 |
| CHEMBL4644352 | — | — | 1 | - |
| CHEMBL85 | RISPERIDONE | 4.0 | 1 | - |
| CHEMBL621 | TRAZODONE | 4.0 | 1 | - |
| CHEMBL4634009 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2105760 | BREXPIPRAZOLE | EC50 | = | 6.3 | nM | 8.20 |
| CHEMBL4638599 | — | EC50 | = | 13.6 | nM | 7.87 |
| CHEMBL4644391 | — | EC50 | = | 27.3 | nM | 7.56 |
| CHEMBL4644352 | — | EC50 | - | — | - | |
| CHEMBL85 | RISPERIDONE | EC50 | - | — | - | |
| CHEMBL621 | TRAZODONE | EC50 | - | — | - | |
| CHEMBL4634009 | — | EC50 | - | — | - |