Assay Detail
Binding
CHEMBL4620353
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Inhibition of IDO1 (unknown origin)
15
Total Activities
15
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Synthesis of novel tryptanthrin derivatives as dual inhibitors of indoleamine 2,3-dioxygenase 1 and tryptophan 2,3-dioxygenase.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 15 | 6.21 | 7.05 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3545369 | EPACADOSTAT | 3.0 | 1 | 7.05 |
| CHEMBL4645973 | — | — | 1 | 6.92 |
| CHEMBL4648181 | — | — | 1 | 6.72 |
| CHEMBL4643029 | — | — | 1 | 6.34 |
| CHEMBL4646483 | — | — | 1 | 6.34 |
| CHEMBL4646657 | — | — | 1 | 6.32 |
| CHEMBL4647345 | — | — | 1 | 6.26 |
| CHEMBL4633682 | — | — | 1 | 6.24 |
| CHEMBL4644380 | — | — | 1 | 6.11 |
| CHEMBL4645897 | — | — | 1 | 5.92 |
| CHEMBL4643729 | — | — | 1 | 5.84 |
| CHEMBL4635512 | — | — | 1 | 5.75 |
| CHEMBL4644195 | — | — | 1 | 4.88 |
| CHEMBL1812545 | — | — | 1 | - |
| CHEMBL4161733 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3545369 | EPACADOSTAT | IC50 | = | 90.0 | nM | 7.05 |
| CHEMBL4645973 | — | IC50 | = | 120.0 | nM | 6.92 |
| CHEMBL4648181 | — | IC50 | = | 190.0 | nM | 6.72 |
| CHEMBL4643029 | — | IC50 | = | 460.0 | nM | 6.34 |
| CHEMBL4646483 | — | IC50 | = | 460.0 | nM | 6.34 |
| CHEMBL4646657 | — | IC50 | = | 480.0 | nM | 6.32 |
| CHEMBL4647345 | — | IC50 | = | 550.0 | nM | 6.26 |
| CHEMBL4633682 | — | IC50 | = | 570.0 | nM | 6.24 |
| CHEMBL4644380 | — | IC50 | = | 780.0 | nM | 6.11 |
| CHEMBL4645897 | — | IC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL4643729 | — | IC50 | = | 1430.0 | nM | 5.84 |
| CHEMBL4635512 | — | IC50 | = | 1790.0 | nM | 5.75 |
| CHEMBL4644195 | — | IC50 | = | 13090.0 | nM | 4.88 |
| CHEMBL1812545 | — | IC50 | - | — | - | |
| CHEMBL4161733 | — | IC50 | = | 1.1 | nM | - |