Assay Detail
Functional
CHEMBL4620772
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Antiproliferative activity against human HeLa cells after 96 hrs by crystal violet staining based assay
31
Total Activities
31
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HeLa |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Treating Cancer by Spindle Assembly Checkpoint Abrogation: Discovery of Two Clinical Candidates, BAY 1161909 and BAY 1217389, Targeting MPS1 Kinase.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 31 | 6.42 | 8.34 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4634997 | — | — | 1 | 8.34 |
| CHEMBL4456085 | BAY-1217389 | 1.0 | 1 | 8.12 |
| CHEMBL4638914 | — | — | 1 | 7.58 |
| CHEMBL4645182 | — | — | 1 | 7.43 |
| CHEMBL4636046 | — | — | 1 | 7.30 |
| CHEMBL4642491 | — | — | 1 | 7.24 |
| CHEMBL4632416 | — | — | 1 | 7.17 |
| CHEMBL4632740 | — | — | 1 | 7.07 |
| CHEMBL4640261 | — | — | 1 | 6.92 |
| CHEMBL4636230 | — | — | 1 | 6.85 |
| CHEMBL4638962 | — | — | 1 | 6.70 |
| CHEMBL4632648 | — | — | 1 | 6.61 |
| CHEMBL4635693 | — | — | 1 | 6.58 |
| CHEMBL4303241 | BAY-1161909 | 2.0 | 1 | 6.58 |
| CHEMBL4646001 | — | — | 1 | 6.57 |
| CHEMBL4581793 | — | — | 1 | 6.16 |
| CHEMBL4638150 | — | — | 1 | 6.14 |
| CHEMBL4637496 | — | — | 1 | 5.89 |
| CHEMBL4635532 | — | — | 1 | 5.81 |
| CHEMBL4640148 | — | — | 1 | 5.64 |
| CHEMBL3940165 | — | — | 1 | 5.61 |
| CHEMBL4632548 | — | — | 1 | 5.29 |
| CHEMBL4643569 | — | — | 1 | 5.23 |
| CHEMBL4632856 | — | — | 1 | 5.16 |
| CHEMBL4641881 | — | — | 1 | 5.12 |
| CHEMBL4637247 | — | — | 1 | 5.11 |
| CHEMBL4646621 | — | — | 1 | 5.02 |
| CHEMBL4633800 | — | — | 1 | - |
| CHEMBL3974070 | — | — | 1 | - |
| CHEMBL4649394 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4634997 | — | IC50 | = | 4.6 | nM | 8.34 |
| CHEMBL4456085 | BAY-1217389 | IC50 | = | 7.6 | nM | 8.12 |
| CHEMBL4638914 | — | IC50 | = | 26.0 | nM | 7.58 |
| CHEMBL4645182 | — | IC50 | = | 37.0 | nM | 7.43 |
| CHEMBL4636046 | — | IC50 | = | 50.0 | nM | 7.30 |
| CHEMBL4642491 | — | IC50 | = | 57.0 | nM | 7.24 |
| CHEMBL4632416 | — | IC50 | = | 67.0 | nM | 7.17 |
| CHEMBL4632740 | — | IC50 | = | 85.0 | nM | 7.07 |
| CHEMBL4640261 | — | IC50 | = | 120.0 | nM | 6.92 |
| CHEMBL4636230 | — | IC50 | = | 140.0 | nM | 6.85 |
| CHEMBL4638962 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL4632648 | — | IC50 | = | 246.0 | nM | 6.61 |
| CHEMBL4635693 | — | IC50 | = | 266.0 | nM | 6.58 |
| CHEMBL4303241 | BAY-1161909 | IC50 | = | 260.0 | nM | 6.58 |
| CHEMBL4646001 | — | IC50 | = | 270.0 | nM | 6.57 |
| CHEMBL4581793 | — | IC50 | = | 695.0 | nM | 6.16 |
| CHEMBL4638150 | — | IC50 | = | 725.0 | nM | 6.14 |
| CHEMBL4637496 | — | IC50 | = | 1290.0 | nM | 5.89 |
| CHEMBL4635532 | — | IC50 | = | 1550.0 | nM | 5.81 |
| CHEMBL4640148 | — | IC50 | = | 2300.0 | nM | 5.64 |
| CHEMBL3940165 | — | IC50 | = | 2480.0 | nM | 5.61 |
| CHEMBL4632548 | — | IC50 | = | 5140.0 | nM | 5.29 |
| CHEMBL4643569 | — | IC50 | = | 5900.0 | nM | 5.23 |
| CHEMBL4632856 | — | IC50 | = | 7000.0 | nM | 5.16 |
| CHEMBL4641881 | — | IC50 | = | 7500.0 | nM | 5.12 |
| CHEMBL4637247 | — | IC50 | = | 7730.0 | nM | 5.11 |
| CHEMBL4646621 | — | IC50 | = | 9590.0 | nM | 5.02 |
| CHEMBL4633800 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL3974070 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4649394 | — | IC50 | > | 3000.0 | nM | - |
| CHEMBL4638692 | — | IC50 | > | 10000.0 | nM | - |