Assay Detail
Functional
CHEMBL4620796
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiproliferative activity against human HT-29 cells after 96 hrs by crystal violet staining based assay
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HT-29 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Treating Cancer by Spindle Assembly Checkpoint Abrogation: Discovery of Two Clinical Candidates, BAY 1161909 and BAY 1217389, Targeting MPS1 Kinase.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 6.69 | 7.21 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4456085 | BAY-1217389 | 1.0 | 1 | 7.21 |
| CHEMBL4640247 | — | — | 1 | 6.74 |
| CHEMBL4645348 | — | — | 1 | 6.56 |
| CHEMBL4469414 | LUVIXASERTIB | 2.0 | 1 | 6.25 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4456085 | BAY-1217389 | IC50 | = | 62.0 | nM | 7.21 |
| CHEMBL4640247 | — | IC50 | = | 183.0 | nM | 6.74 |
| CHEMBL4645348 | — | IC50 | = | 276.0 | nM | 6.56 |
| CHEMBL4469414 | LUVIXASERTIB | IC50 | = | 557.0 | nM | 6.25 |