Assay Detail
Binding
CHEMBL4620868
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of GFP-fused RSV 224 fusion protein infected in human HeLa cells assessed as reduction in viral replication after 3 days by laser microscopic analysis
68
Total Activities
68
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Respiratory syncytial virus |
| Cell Type | HeLa |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Target
Fusion glycoprotein F0 (CHEMBL2364165) ↗| Type | SINGLE PROTEIN |
| Organism | Human respiratory syncytial virus |
Publication
Discovery of 3-({5-Chloro-1-[3-(methylsulfonyl)propyl]-1H-indol-2-yl}methyl)-1-(2,2,2-trifluoroethyl)-1,3-dihydro-2H-imidazo[4,5-c]pyridin-2-one (JNJ-53718678), a Potent and Orally Bioavailable Fusion Inhibitor of Respiratory Syncytial Virus.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 68 | 8.51 | 10.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4645289 | — | — | 1 | 10.00 |
| CHEMBL4633144 | — | — | 1 | 9.70 |
| CHEMBL4639647 | — | — | 1 | 9.70 |
| CHEMBL4647497 | — | — | 1 | 9.70 |
| CHEMBL4642009 | — | — | 1 | 9.60 |
| CHEMBL4635306 | — | — | 1 | 9.60 |
| CHEMBL4644121 | — | — | 1 | 9.60 |
| CHEMBL4644338 | — | — | 1 | 9.60 |
| CHEMBL4644767 | — | — | 1 | 9.50 |
| CHEMBL4639685 | — | — | 1 | 9.50 |
| CHEMBL4637901 | — | — | 1 | 9.40 |
| CHEMBL4634123 | — | — | 1 | 9.40 |
| CHEMBL4636246 | — | — | 1 | 9.30 |
| CHEMBL4437054 | RILEMATOVIR | 3.0 | 1 | 9.30 |
| CHEMBL4646241 | — | — | 1 | 9.30 |
| CHEMBL4639834 | — | — | 1 | 9.30 |
| CHEMBL4648807 | — | — | 1 | 9.30 |
| CHEMBL4632978 | — | — | 1 | 9.20 |
| CHEMBL4640078 | — | — | 1 | 9.10 |
| CHEMBL4639912 | — | — | 1 | 9.00 |
| CHEMBL4633557 | — | — | 1 | 9.00 |
| CHEMBL4641189 | — | — | 1 | 9.00 |
| CHEMBL4646649 | — | — | 1 | 9.00 |
| CHEMBL4642110 | — | — | 1 | 8.90 |
| CHEMBL4643568 | — | — | 1 | 8.90 |
| CHEMBL4641591 | — | — | 1 | 8.90 |
| CHEMBL4649477 | — | — | 1 | 8.80 |
| CHEMBL4648250 | — | — | 1 | 8.80 |
| CHEMBL4649847 | — | — | 1 | 8.80 |
| CHEMBL4640814 | — | — | 1 | 8.80 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4645289 | — | EC50 | = | 0.1 | nM | 10.00 |
| CHEMBL4633144 | — | EC50 | = | 0.1995 | nM | 9.70 |
| CHEMBL4647497 | — | EC50 | = | 0.1995 | nM | 9.70 |
| CHEMBL4639647 | — | EC50 | = | 0.1995 | nM | 9.70 |
| CHEMBL4642009 | — | EC50 | = | 0.2512 | nM | 9.60 |
| CHEMBL4635306 | — | EC50 | = | 0.2512 | nM | 9.60 |
| CHEMBL4644121 | — | EC50 | = | 0.2512 | nM | 9.60 |
| CHEMBL4644338 | — | EC50 | = | 0.2512 | nM | 9.60 |
| CHEMBL4644767 | — | EC50 | = | 0.3162 | nM | 9.50 |
| CHEMBL4639685 | — | EC50 | = | 0.3162 | nM | 9.50 |
| CHEMBL4637901 | — | EC50 | = | 0.3981 | nM | 9.40 |
| CHEMBL4634123 | — | EC50 | = | 0.3981 | nM | 9.40 |
| CHEMBL4639834 | — | EC50 | = | 0.5012 | nM | 9.30 |
| CHEMBL4437054 | RILEMATOVIR | EC50 | = | 0.5012 | nM | 9.30 |
| CHEMBL4636246 | — | EC50 | = | 0.5012 | nM | 9.30 |
| CHEMBL4646241 | — | EC50 | = | 0.5012 | nM | 9.30 |
| CHEMBL4648807 | — | EC50 | = | 0.5012 | nM | 9.30 |
| CHEMBL4632978 | — | EC50 | = | 0.631 | nM | 9.20 |
| CHEMBL4640078 | — | EC50 | = | 0.7943 | nM | 9.10 |
| CHEMBL4639912 | — | EC50 | = | 1.0 | nM | 9.00 |
| CHEMBL4633557 | — | EC50 | = | 1.0 | nM | 9.00 |
| CHEMBL4641189 | — | EC50 | = | 1.0 | nM | 9.00 |
| CHEMBL4646649 | — | EC50 | = | 1.0 | nM | 9.00 |
| CHEMBL4641591 | — | EC50 | = | 1.259 | nM | 8.90 |
| CHEMBL4642110 | — | EC50 | = | 1.259 | nM | 8.90 |
| CHEMBL4643568 | — | EC50 | = | 1.259 | nM | 8.90 |
| CHEMBL4649477 | — | EC50 | = | 1.585 | nM | 8.80 |
| CHEMBL4648250 | — | EC50 | = | 1.585 | nM | 8.80 |
| CHEMBL4649847 | — | EC50 | = | 1.585 | nM | 8.80 |
| CHEMBL4640814 | — | EC50 | = | 1.585 | nM | 8.80 |
| CHEMBL4643637 | — | EC50 | = | 1.585 | nM | 8.80 |
| CHEMBL4647299 | — | EC50 | = | 1.585 | nM | 8.80 |
| CHEMBL4634198 | — | EC50 | = | 1.585 | nM | 8.80 |
| CHEMBL4637949 | — | EC50 | = | 1.995 | nM | 8.70 |
| CHEMBL4642661 | — | EC50 | = | 1.995 | nM | 8.70 |
| CHEMBL4459588 | — | EC50 | = | 1.995 | nM | 8.70 |
| CHEMBL4648235 | — | EC50 | = | 2.512 | nM | 8.60 |
| CHEMBL4634973 | — | EC50 | = | 2.512 | nM | 8.60 |
| CHEMBL4648595 | — | EC50 | = | 2.512 | nM | 8.60 |
| CHEMBL4645785 | — | EC50 | = | 2.512 | nM | 8.60 |
| CHEMBL4638215 | — | EC50 | = | 3.981 | nM | 8.40 |
| CHEMBL4632407 | — | EC50 | = | 3.981 | nM | 8.40 |
| CHEMBL4642385 | — | EC50 | = | 5.012 | nM | 8.30 |
| CHEMBL4648297 | — | EC50 | = | 5.012 | nM | 8.30 |
| CHEMBL4636317 | — | EC50 | = | 6.31 | nM | 8.20 |
| CHEMBL4637529 | — | EC50 | = | 6.31 | nM | 8.20 |
| CHEMBL4634733 | — | EC50 | = | 7.943 | nM | 8.10 |
| CHEMBL4643207 | — | EC50 | = | 7.943 | nM | 8.10 |
| CHEMBL4639621 | — | EC50 | = | 7.943 | nM | 8.10 |
| CHEMBL243876 | — | EC50 | = | 7.943 | nM | 8.10 |