Assay Detail
Binding
CHEMBL4621277
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Inhibition of pseudotyped HIV/EBOV GP infected in human A549 cells assessed as reduction in virus entry measured after 48 hrs by luciferase reporter gene assay
26
Total Activities
26
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Ebolavirus |
| Cell Type | A549 |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Discovery and Structural Optimization of 4-(Aminomethyl)benzamides as Potent Entry Inhibitors of Ebola and Marburg Virus Infections.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 26 | 6.08 | 7.92 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4638872 | — | — | 1 | 7.92 |
| CHEMBL4647732 | — | — | 1 | 7.75 |
| CHEMBL4644544 | — | — | 1 | 7.46 |
| CHEMBL1655 | TOREMIFENE | 4.0 | 1 | 7.05 |
| CHEMBL4633085 | — | — | 1 | 6.80 |
| CHEMBL4645609 | — | — | 1 | 6.48 |
| CHEMBL4640843 | — | — | 1 | 6.42 |
| CHEMBL4640955 | — | — | 1 | 6.32 |
| CHEMBL4634983 | — | — | 1 | 6.14 |
| CHEMBL4648854 | — | — | 1 | 6.09 |
| CHEMBL4642921 | — | — | 1 | 6.00 |
| CHEMBL4634276 | — | — | 1 | 5.90 |
| CHEMBL4644744 | — | — | 1 | 5.82 |
| CHEMBL4645981 | — | — | 1 | 5.81 |
| CHEMBL4645123 | — | — | 1 | 5.78 |
| CHEMBL4640931 | — | — | 1 | 5.69 |
| CHEMBL4637205 | — | — | 1 | 5.65 |
| CHEMBL4641491 | — | — | 1 | 5.65 |
| CHEMBL4645303 | — | — | 1 | 5.63 |
| CHEMBL4649894 | — | — | 1 | 5.63 |
| CHEMBL4646197 | — | — | 1 | 5.54 |
| CHEMBL4639463 | — | — | 1 | 5.53 |
| CHEMBL4633265 | — | — | 1 | 5.41 |
| CHEMBL4643769 | — | — | 1 | 5.34 |
| CHEMBL4635591 | — | — | 1 | 5.25 |
| CHEMBL4648334 | — | — | 1 | 5.01 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4638872 | — | EC50 | = | 12.0 | nM | 7.92 |
| CHEMBL4647732 | — | EC50 | = | 18.0 | nM | 7.75 |
| CHEMBL4644544 | — | EC50 | = | 35.0 | nM | 7.46 |
| CHEMBL1655 | TOREMIFENE | EC50 | = | 90.0 | nM | 7.05 |
| CHEMBL4633085 | — | EC50 | = | 160.0 | nM | 6.80 |
| CHEMBL4645609 | — | EC50 | = | 330.0 | nM | 6.48 |
| CHEMBL4640843 | — | EC50 | = | 380.0 | nM | 6.42 |
| CHEMBL4640955 | — | EC50 | = | 480.0 | nM | 6.32 |
| CHEMBL4634983 | — | EC50 | = | 730.0 | nM | 6.14 |
| CHEMBL4648854 | — | EC50 | = | 820.0 | nM | 6.09 |
| CHEMBL4642921 | — | EC50 | = | 990.0 | nM | 6.00 |
| CHEMBL4634276 | — | EC50 | = | 1270.0 | nM | 5.90 |
| CHEMBL4644744 | — | EC50 | = | 1520.0 | nM | 5.82 |
| CHEMBL4645981 | — | EC50 | = | 1560.0 | nM | 5.81 |
| CHEMBL4645123 | — | EC50 | = | 1680.0 | nM | 5.78 |
| CHEMBL4640931 | — | EC50 | = | 2050.0 | nM | 5.69 |
| CHEMBL4637205 | — | EC50 | = | 2220.0 | nM | 5.65 |
| CHEMBL4641491 | — | EC50 | = | 2220.0 | nM | 5.65 |
| CHEMBL4645303 | — | EC50 | = | 2320.0 | nM | 5.63 |
| CHEMBL4649894 | — | EC50 | = | 2340.0 | nM | 5.63 |
| CHEMBL4646197 | — | EC50 | = | 2870.0 | nM | 5.54 |
| CHEMBL4639463 | — | EC50 | = | 2970.0 | nM | 5.53 |
| CHEMBL4633265 | — | EC50 | = | 3870.0 | nM | 5.41 |
| CHEMBL4643769 | — | EC50 | = | 4570.0 | nM | 5.34 |
| CHEMBL4635591 | — | EC50 | = | 5600.0 | nM | 5.25 |
| CHEMBL4648334 | — | EC50 | = | 9860.0 | nM | 5.01 |