Assay Detail
Binding
CHEMBL4621279
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Inhibition of pseudotyped HIV/MARV GP infected in human A549 cells assessed as reduction in virus entry measured after 48 hrs by luciferase reporter gene assay
25
Total Activities
25
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Marburgvirus |
| Cell Type | A549 |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Discovery and Structural Optimization of 4-(Aminomethyl)benzamides as Potent Entry Inhibitors of Ebola and Marburg Virus Infections.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 25 | 5.77 | 6.75 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4638872 | — | — | 1 | 6.75 |
| CHEMBL4644544 | — | — | 1 | 6.42 |
| CHEMBL4648334 | — | — | 1 | 6.28 |
| CHEMBL4645609 | — | — | 1 | 6.07 |
| CHEMBL4642921 | — | — | 1 | 6.02 |
| CHEMBL4644744 | — | — | 1 | 5.91 |
| CHEMBL4640843 | — | — | 1 | 5.88 |
| CHEMBL4639463 | — | — | 1 | 5.85 |
| CHEMBL4645123 | — | — | 1 | 5.84 |
| CHEMBL4634983 | — | — | 1 | 5.79 |
| CHEMBL4634276 | — | — | 1 | 5.79 |
| CHEMBL4645981 | — | — | 1 | 5.76 |
| CHEMBL4648854 | — | — | 1 | 5.73 |
| CHEMBL4649894 | — | — | 1 | 5.69 |
| CHEMBL4646197 | — | — | 1 | 5.68 |
| CHEMBL4637205 | — | — | 1 | 5.64 |
| CHEMBL4640955 | — | — | 1 | 5.63 |
| CHEMBL4643769 | — | — | 1 | 5.58 |
| CHEMBL4647732 | — | — | 1 | 5.55 |
| CHEMBL4641491 | — | — | 1 | 5.54 |
| CHEMBL4640931 | — | — | 1 | 5.51 |
| CHEMBL4633085 | — | — | 1 | 5.50 |
| CHEMBL4635591 | — | — | 1 | 5.44 |
| CHEMBL4633265 | — | — | 1 | 5.24 |
| CHEMBL4645303 | — | — | 1 | 5.11 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4638872 | — | EC50 | = | 180.0 | nM | 6.75 |
| CHEMBL4644544 | — | EC50 | = | 380.0 | nM | 6.42 |
| CHEMBL4648334 | — | EC50 | = | 530.0 | nM | 6.28 |
| CHEMBL4645609 | — | EC50 | = | 850.0 | nM | 6.07 |
| CHEMBL4642921 | — | EC50 | = | 960.0 | nM | 6.02 |
| CHEMBL4644744 | — | EC50 | = | 1240.0 | nM | 5.91 |
| CHEMBL4640843 | — | EC50 | = | 1330.0 | nM | 5.88 |
| CHEMBL4639463 | — | EC50 | = | 1410.0 | nM | 5.85 |
| CHEMBL4645123 | — | EC50 | = | 1460.0 | nM | 5.84 |
| CHEMBL4634983 | — | EC50 | = | 1630.0 | nM | 5.79 |
| CHEMBL4634276 | — | EC50 | = | 1610.0 | nM | 5.79 |
| CHEMBL4645981 | — | EC50 | = | 1730.0 | nM | 5.76 |
| CHEMBL4648854 | — | EC50 | = | 1880.0 | nM | 5.73 |
| CHEMBL4649894 | — | EC50 | = | 2050.0 | nM | 5.69 |
| CHEMBL4646197 | — | EC50 | = | 2100.0 | nM | 5.68 |
| CHEMBL4637205 | — | EC50 | = | 2310.0 | nM | 5.64 |
| CHEMBL4640955 | — | EC50 | = | 2340.0 | nM | 5.63 |
| CHEMBL4643769 | — | EC50 | = | 2650.0 | nM | 5.58 |
| CHEMBL4647732 | — | EC50 | = | 2790.0 | nM | 5.55 |
| CHEMBL4641491 | — | EC50 | = | 2900.0 | nM | 5.54 |
| CHEMBL4640931 | — | EC50 | = | 3090.0 | nM | 5.51 |
| CHEMBL4633085 | — | EC50 | = | 3180.0 | nM | 5.50 |
| CHEMBL4635591 | — | EC50 | = | 3650.0 | nM | 5.44 |
| CHEMBL4633265 | — | EC50 | = | 5700.0 | nM | 5.24 |
| CHEMBL4645303 | — | EC50 | = | 7740.0 | nM | 5.11 |