Assay Detail
Binding
CHEMBL4621577
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of Dengue virus serotype 2 NS2B-NS3 protease expressed in Escherichia coli BL21 lambda (DE3) cells using Abz-Nle-Lys-Arg-Arg-Ser-3-(NO2)Tyr as substrate preincubated for 15 mins followed by substrate addition and measured for 15 mins by FRET assay
59
Total Activities
56
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | dengue virus type 2 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
A New Class of Dengue and West Nile Virus Protease Inhibitors with Submicromolar Activity in Reporter Gene DENV-2 Protease and Viral Replication Assays.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 56 | 5.28 | 6.27 |
| Ki | 3 | 5.59 | 6.34 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4633312 | — | — | 2 | 6.34 |
| CHEMBL3741422 | — | — | 1 | 6.17 |
| CHEMBL4640021 | — | — | 1 | 5.89 |
| CHEMBL4633204 | — | — | 1 | 5.75 |
| CHEMBL4638299 | — | — | 1 | 5.70 |
| CHEMBL4634176 | — | — | 1 | 5.66 |
| CHEMBL4649657 | — | — | 1 | 5.64 |
| CHEMBL4636584 | — | — | 1 | 5.60 |
| CHEMBL4649859 | — | — | 1 | 5.54 |
| CHEMBL4642885 | — | — | 1 | 5.51 |
| CHEMBL4640386 | — | — | 2 | 5.42 |
| CHEMBL4634331 | — | — | 1 | 5.40 |
| CHEMBL4646812 | — | — | 1 | 5.36 |
| CHEMBL4639241 | — | — | 1 | 5.33 |
| CHEMBL4641383 | — | — | 1 | 5.32 |
| CHEMBL4643221 | — | — | 1 | 5.31 |
| CHEMBL4638743 | — | — | 1 | 5.24 |
| CHEMBL4646053 | — | — | 1 | 5.23 |
| CHEMBL4645091 | — | — | 1 | 5.18 |
| CHEMBL4632524 | — | — | 1 | 5.17 |
| CHEMBL4641816 | — | — | 1 | 5.13 |
| CHEMBL4638781 | — | — | 1 | 5.05 |
| CHEMBL4649655 | — | — | 2 | 5.01 |
| CHEMBL4638581 | — | — | 1 | 4.89 |
| CHEMBL4802111 | — | — | 1 | 4.85 |
| CHEMBL4633636 | — | — | 1 | 4.72 |
| CHEMBL3335490 | — | — | 1 | 4.64 |
| CHEMBL4642710 | — | — | 1 | 4.62 |
| CHEMBL4638202 | — | — | 1 | 4.52 |
| CHEMBL4635643 | — | — | 1 | 4.40 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4633312 | — | Ki | = | 460.0 | nM | 6.34 |
| CHEMBL4633312 | — | IC50 | = | 540.0 | nM | 6.27 |
| CHEMBL3741422 | — | IC50 | = | 680.0 | nM | 6.17 |
| CHEMBL4640021 | — | IC50 | = | 1300.0 | nM | 5.89 |
| CHEMBL4633204 | — | IC50 | = | 1800.0 | nM | 5.75 |
| CHEMBL4638299 | — | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL4634176 | — | IC50 | = | 2200.0 | nM | 5.66 |
| CHEMBL4649657 | — | IC50 | = | 2300.0 | nM | 5.64 |
| CHEMBL4636584 | — | IC50 | = | 2500.0 | nM | 5.60 |
| CHEMBL4649859 | — | IC50 | = | 2900.0 | nM | 5.54 |
| CHEMBL4642885 | — | IC50 | = | 3100.0 | nM | 5.51 |
| CHEMBL4640386 | — | Ki | = | 3800.0 | nM | 5.42 |
| CHEMBL4634331 | — | IC50 | = | 4000.0 | nM | 5.40 |
| CHEMBL4646812 | — | IC50 | = | 4400.0 | nM | 5.36 |
| CHEMBL4639241 | — | IC50 | = | 4700.0 | nM | 5.33 |
| CHEMBL4641383 | — | IC50 | = | 4800.0 | nM | 5.32 |
| CHEMBL4643221 | — | IC50 | = | 4900.0 | nM | 5.31 |
| CHEMBL4640386 | — | IC50 | = | 4900.0 | nM | 5.31 |
| CHEMBL4638743 | — | IC50 | = | 5700.0 | nM | 5.24 |
| CHEMBL4646053 | — | IC50 | = | 5900.0 | nM | 5.23 |
| CHEMBL4645091 | — | IC50 | = | 6600.0 | nM | 5.18 |
| CHEMBL4632524 | — | IC50 | = | 6800.0 | nM | 5.17 |
| CHEMBL4641816 | — | IC50 | = | 7400.0 | nM | 5.13 |
| CHEMBL4638781 | — | IC50 | = | 9000.0 | nM | 5.05 |
| CHEMBL4649655 | — | Ki | = | 9800.0 | nM | 5.01 |
| CHEMBL4649655 | — | IC50 | = | 11000.0 | nM | 4.96 |
| CHEMBL4638581 | — | IC50 | = | 13000.0 | nM | 4.89 |
| CHEMBL4802111 | — | IC50 | = | 14000.0 | nM | 4.85 |
| CHEMBL4633636 | — | IC50 | = | 19000.0 | nM | 4.72 |
| CHEMBL3335490 | — | IC50 | = | 23000.0 | nM | 4.64 |
| CHEMBL4642710 | — | IC50 | = | 24000.0 | nM | 4.62 |
| CHEMBL4638202 | — | IC50 | = | 30000.0 | nM | 4.52 |
| CHEMBL4635643 | — | IC50 | = | 40000.0 | nM | 4.40 |
| CHEMBL4636025 | — | IC50 | - | — | - | |
| CHEMBL4636972 | — | IC50 | - | — | - | |
| CHEMBL4646913 | — | IC50 | - | — | - | |
| CHEMBL4640682 | — | IC50 | - | — | - | |
| CHEMBL4640656 | — | IC50 | - | — | - | |
| CHEMBL4635612 | — | IC50 | - | — | - | |
| CHEMBL4634164 | — | IC50 | - | — | - | |
| CHEMBL4635939 | — | IC50 | - | — | - | |
| CHEMBL4640965 | — | IC50 | - | — | - | |
| CHEMBL4646482 | — | IC50 | - | — | - | |
| CHEMBL4645960 | — | IC50 | - | — | - | |
| CHEMBL4647630 | — | IC50 | - | — | - | |
| CHEMBL4634206 | — | IC50 | - | — | - | |
| CHEMBL4632939 | — | IC50 | - | — | - | |
| CHEMBL4649399 | — | IC50 | - | — | - | |
| CHEMBL4634622 | — | IC50 | - | — | - | |
| CHEMBL4640172 | — | IC50 | - | — | - |