Assay Detail
Functional
CHEMBL4621658
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Cytotoxicity against human NCI-H226 cells assessed as reduction in cell viability measured after 72 hrs by CellTiter 96 aqueous one solution assay
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | NCI-H226 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Characterization of TnmH as an <i>O</i>-Methyltransferase Revealing Insights into Tiancimycin Biosynthesis and Enabling a Biocatalytic Strategy To Prepare Antibody-Tiancimycin Conjugates.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 7 | 7.62 | 8.43 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4648960 | — | — | 1 | 8.43 |
| CHEMBL4636420 | — | — | 1 | 8.38 |
| CHEMBL4635291 | — | — | 1 | 7.58 |
| CHEMBL4633528 | — | — | 1 | 7.50 |
| CHEMBL4639420 | — | — | 1 | 7.18 |
| CHEMBL4634658 | — | — | 1 | 7.17 |
| CHEMBL4634930 | — | — | 1 | 7.12 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4648960 | — | EC50 | = | 3.7 | nM | 8.43 |
| CHEMBL4636420 | — | EC50 | = | 4.2 | nM | 8.38 |
| CHEMBL4635291 | — | EC50 | = | 26.0 | nM | 7.58 |
| CHEMBL4633528 | — | EC50 | = | 32.0 | nM | 7.50 |
| CHEMBL4639420 | — | EC50 | = | 66.0 | nM | 7.18 |
| CHEMBL4634658 | — | EC50 | = | 68.0 | nM | 7.17 |
| CHEMBL4634930 | — | EC50 | = | 75.0 | nM | 7.12 |