Assay Detail
Functional
CHEMBL4621667
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antileishmanial activity against Leishmania donovani amastigotes infected in human THP1 cells incubated for 96 hrs
36
Total Activities
36
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Leishmania donovani |
| Cell Type | THP-1 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Identification and Optimization of a Series of 8-Hydroxy Naphthyridines with Potent <i>In Vitro</i> Antileishmanial Activity: Initial SAR and Assessment of <i>In Vivo</i> Activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 36 | 5.75 | 7.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4644333 | — | — | 1 | 7.00 |
| CHEMBL4645906 | — | — | 1 | 6.80 |
| CHEMBL267345 | AMPHOTERICIN B | 4.0 | 1 | 6.70 |
| CHEMBL523303 | — | — | 1 | 6.50 |
| CHEMBL4648046 | — | — | 1 | 6.30 |
| CHEMBL3290936 | — | — | 1 | 6.30 |
| CHEMBL4635381 | — | — | 1 | 6.20 |
| CHEMBL4644580 | — | — | 1 | 6.00 |
| CHEMBL4645520 | — | — | 1 | 5.90 |
| CHEMBL4644468 | — | — | 1 | 5.90 |
| CHEMBL4635260 | — | — | 1 | 5.80 |
| CHEMBL4644369 | — | — | 1 | 5.70 |
| CHEMBL522630 | — | — | 1 | 5.60 |
| CHEMBL4648017 | — | — | 1 | 5.60 |
| CHEMBL125 | MILTEFOSINE | 4.0 | 1 | 5.40 |
| CHEMBL4634437 | — | — | 1 | 5.30 |
| CHEMBL4648588 | — | — | 1 | 5.30 |
| CHEMBL4648127 | — | — | 1 | 5.00 |
| CHEMBL4639773 | — | — | 1 | 5.00 |
| CHEMBL221027 | — | — | 1 | 4.80 |
| CHEMBL4646679 | — | — | 1 | 4.80 |
| CHEMBL4648421 | — | — | 1 | 4.50 |
| CHEMBL4639444 | — | — | 1 | - |
| CHEMBL4632697 | — | — | 1 | - |
| CHEMBL4645383 | — | — | 1 | - |
| CHEMBL4644400 | — | — | 1 | - |
| CHEMBL254316 | RALTEGRAVIR | 4.0 | 1 | - |
| CHEMBL4633833 | — | — | 1 | - |
| CHEMBL4644356 | — | — | 1 | - |
| CHEMBL4645046 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4644333 | — | EC50 | = | 100.0 | nM | 7.00 |
| CHEMBL4645906 | — | EC50 | = | 158.49 | nM | 6.80 |
| CHEMBL267345 | AMPHOTERICIN B | EC50 | = | 199.53 | nM | 6.70 |
| CHEMBL523303 | — | EC50 | = | 316.23 | nM | 6.50 |
| CHEMBL4648046 | — | EC50 | = | 501.19 | nM | 6.30 |
| CHEMBL3290936 | — | EC50 | = | 501.19 | nM | 6.30 |
| CHEMBL4635381 | — | EC50 | = | 630.96 | nM | 6.20 |
| CHEMBL4644580 | — | EC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL4645520 | — | EC50 | = | 1258.93 | nM | 5.90 |
| CHEMBL4644468 | — | EC50 | = | 1258.93 | nM | 5.90 |
| CHEMBL4635260 | — | EC50 | = | 1584.89 | nM | 5.80 |
| CHEMBL4644369 | — | EC50 | = | 1995.26 | nM | 5.70 |
| CHEMBL522630 | — | EC50 | = | 2511.89 | nM | 5.60 |
| CHEMBL4648017 | — | EC50 | = | 2511.89 | nM | 5.60 |
| CHEMBL125 | MILTEFOSINE | EC50 | = | 3981.07 | nM | 5.40 |
| CHEMBL4634437 | — | EC50 | = | 5011.87 | nM | 5.30 |
| CHEMBL4648588 | — | EC50 | = | 5011.87 | nM | 5.30 |
| CHEMBL4639773 | — | EC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL4648127 | — | EC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL221027 | — | EC50 | = | 15848.93 | nM | 4.80 |
| CHEMBL4646679 | — | EC50 | = | 15848.93 | nM | 4.80 |
| CHEMBL4648421 | — | EC50 | = | 31622.78 | nM | 4.50 |
| CHEMBL4642833 | — | EC50 | > | 50118.72 | nM | - |
| CHEMBL4633980 | — | EC50 | > | 50118.72 | nM | - |
| CHEMBL4632762 | — | EC50 | > | 50118.72 | nM | - |
| CHEMBL4649578 | — | EC50 | > | 50118.72 | nM | - |
| CHEMBL4639318 | — | EC50 | > | 50118.72 | nM | - |
| CHEMBL4646137 | — | EC50 | > | 50118.72 | nM | - |
| CHEMBL4645046 | — | EC50 | > | 50118.72 | nM | - |
| CHEMBL4644356 | — | EC50 | > | 50118.72 | nM | - |
| CHEMBL4633833 | — | EC50 | > | 50118.72 | nM | - |
| CHEMBL254316 | RALTEGRAVIR | EC50 | > | 50118.72 | nM | - |
| CHEMBL4644400 | — | EC50 | > | 50118.72 | nM | - |
| CHEMBL4645383 | — | EC50 | > | 50118.72 | nM | - |
| CHEMBL4632697 | — | EC50 | > | 50118.72 | nM | - |
| CHEMBL4639444 | — | EC50 | > | 50118.72 | nM | - |