Assay Detail

CHEMBL4621692

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Functional

Antiviral activity against SARS coronavirus infected in primary HAE cells

ChEMBL ↗

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Target

SARS-CoV (CHEMBL4303836) ↗

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Primary target SARS-CoV

CHEMBL4303836

Anchored from Assay target.

Protein identity SARS-CoV

Disease frame Disease evidence pending

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Total Activities

Compounds Tested

Activity Types

Assay Parameters

Assay Information

Assay Type	Functional
Organism	Severe acute respiratory syndrome-related coronavirus
Confidence	1 — Organism
Curated By	Autocuration

Target

SARS-CoV (CHEMBL4303836) ↗

Type	ORGANISM
Organism	Severe acute respiratory syndrome-related coronavirus

Publication

Advantages of the Parent Nucleoside GS-441524 over Remdesivir for Covid-19 Treatment.

Yan VC, Muller FL.
ACS Med Chem Lett (2020) 11 : 1361 -1366
PubMed 32665809 · DOI

Activity Statistics

Type	Count	Avg pChEMBL	Best pChEMBL
EC50	2	6.96	7.16

Compounds Tested

Compound	Name	Phase	Activities	Best pChEMBL
CHEMBL4065616	REMDESIVIR	4.0	1	7.16
CHEMBL2016761	RDV-TP	-1.0	1	6.75

Activity Data

Compound	Name	Type	Rel.	Value	Units	pChEMBL
CHEMBL4065616	REMDESIVIR	EC50	=	69.0	nM	7.16
CHEMBL2016761	RDV-TP	EC50	=	180.0	nM	6.75