Assay Detail
ADMET
CHEMBL4621994
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Cytotoxicity against human D423 cells with ENO1 deficient assessed as reduction in cell viability incubated for 5 days in presence of 21 % oxygen by crystal violet staining based spectrophotometry
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | ADMET |
| Organism | Homo sapiens |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Bioreducible Phosphonoamidate Pro-drug Inhibitor of Enolase: Proof of Concept Study.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 6.37 | 7.10 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4647008 | — | — | 1 | 7.10 |
| CHEMBL4643988 | — | — | 1 | 6.52 |
| CHEMBL260046 | EVOFOSFAMIDE | 3.0 | 1 | 5.50 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4647008 | — | IC50 | = | 79.0 | nM | 7.10 |
| CHEMBL4643988 | — | IC50 | = | 299.0 | nM | 6.52 |
| CHEMBL260046 | EVOFOSFAMIDE | IC50 | = | 3202.0 | nM | 5.50 |