Assay Detail
ADMET
CHEMBL4621997
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Cytotoxicity against human D423 cells with ENO1 deficient assessed as reduction in cell viability incubated for 5 days in presence of 1 % oxygen by crystal violet staining based spectrophotometry
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | ADMET |
| Organism | Homo sapiens |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Bioreducible Phosphonoamidate Pro-drug Inhibitor of Enolase: Proof of Concept Study.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 6.65 | 6.87 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4643988 | — | — | 1 | 6.87 |
| CHEMBL4647008 | — | — | 1 | 6.70 |
| CHEMBL260046 | EVOFOSFAMIDE | 3.0 | 1 | 6.39 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4643988 | — | IC50 | = | 136.0 | nM | 6.87 |
| CHEMBL4647008 | — | IC50 | = | 201.0 | nM | 6.70 |
| CHEMBL260046 | EVOFOSFAMIDE | IC50 | = | 404.0 | nM | 6.39 |