Assay Detail
Binding
CHEMBL4622294
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Inhibition of MRS4174 binding to mouse P2Y14R expressed in HEK293 cells pre-incubated for 30 mins before MRS4174 addition and further incubated for 30 mins by flow cytomtery based competitive fluorescence assay
13
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Mus musculus |
| Cell Type | HEK293 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Exploration of Alternative Scaffolds for P2Y<sub>14</sub> Receptor Antagonists Containing a Biaryl Core.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 13 | 6.73 | 7.67 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4645216 | — | — | 1 | 7.67 |
| CHEMBL1800685 | PPTN | — | 1 | 7.67 |
| CHEMBL4642592 | — | — | 1 | 7.53 |
| CHEMBL4640370 | — | — | 1 | 7.25 |
| CHEMBL4212441 | — | — | 1 | 6.89 |
| CHEMBL4454538 | — | — | 1 | 6.85 |
| CHEMBL4633982 | — | — | 1 | 6.61 |
| CHEMBL4212721 | — | — | 1 | 6.42 |
| CHEMBL4649194 | — | — | 1 | 6.31 |
| CHEMBL4645987 | — | — | 1 | 6.30 |
| CHEMBL4646514 | — | — | 1 | 6.07 |
| CHEMBL4299805 | — | — | 1 | 6.04 |
| CHEMBL4637158 | — | — | 1 | 5.94 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4645216 | — | IC50 | = | 21.4 | nM | 7.67 |
| CHEMBL1800685 | PPTN | IC50 | = | 21.6 | nM | 7.67 |
| CHEMBL4642592 | — | IC50 | = | 29.7 | nM | 7.53 |
| CHEMBL4640370 | — | IC50 | = | 56.3 | nM | 7.25 |
| CHEMBL4212441 | — | IC50 | = | 130.0 | nM | 6.89 |
| CHEMBL4454538 | — | IC50 | = | 142.0 | nM | 6.85 |
| CHEMBL4633982 | — | IC50 | = | 246.0 | nM | 6.61 |
| CHEMBL4212721 | — | IC50 | = | 384.0 | nM | 6.42 |
| CHEMBL4649194 | — | IC50 | = | 487.0 | nM | 6.31 |
| CHEMBL4645987 | — | IC50 | = | 499.0 | nM | 6.30 |
| CHEMBL4646514 | — | IC50 | = | 845.0 | nM | 6.07 |
| CHEMBL4299805 | — | IC50 | = | 902.0 | nM | 6.04 |
| CHEMBL4637158 | — | IC50 | = | 1160.0 | nM | 5.94 |