Assay Detail
Binding
CHEMBL4623096
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Inhibition of bacteria NMD-1
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Bacteria |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
A novel potent metal-binding NDM-1 inhibitor was identified by fragment virtual, SPR and NMR screening.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 5.79 | 8.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4463697 | — | — | 1 | 8.00 |
| CHEMBL4461260 | — | — | 1 | 7.54 |
| CHEMBL51085 | EBSELEN | 3.0 | 1 | 6.42 |
| CHEMBL10247 | THIORPHAN | -1.0 | 1 | 5.75 |
| CHEMBL4059535 | — | — | 1 | 5.16 |
| CHEMBL76577 | — | — | 1 | 5.10 |
| CHEMBL4639950 | — | — | 1 | 4.64 |
| CHEMBL1560 | CAPTOPRIL | 4.0 | 1 | 3.69 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4463697 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL4461260 | — | IC50 | = | 29.0 | nM | 7.54 |
| CHEMBL51085 | EBSELEN | IC50 | = | 380.0 | nM | 6.42 |
| CHEMBL10247 | THIORPHAN | IC50 | = | 1800.0 | nM | 5.75 |
| CHEMBL4059535 | — | IC50 | = | 7000.0 | nM | 5.16 |
| CHEMBL76577 | — | IC50 | = | 7900.0 | nM | 5.10 |
| CHEMBL4639950 | — | IC50 | = | 23000.0 | nM | 4.64 |
| CHEMBL1560 | CAPTOPRIL | IC50 | = | 202000.0 | nM | 3.69 |