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Assay Detail

CHEMBL4623364

Review assay metadata, readout intent, target linkage, and publication context from the same page.

ADMET
Inhibition of HDAC6 (unknown origin)
36
Total Activities
36
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type ADMET
Organism Homo sapiens
Confidence 9 — Direct single protein target
Curated By Autocuration

Target

Histone deacetylase 6 (CHEMBL1865)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Discovery of ethyl ketone-based HDACs 1, 2, and 3 selective inhibitors for HIV latency reactivation.
Yu W, Liu J, Yu Y, Zhang V, Clausen D, Kelly J, Wolkenberg S, Beshore D, Duffy JL, Chung CC, Myers RW, Klein DJ, Fells J, Holloway K, Wu J, Wu G, Howell BJ, Barnard RJO, Kozlowski J.
Bioorg Med Chem Lett (2020) 30 : 127197 -127197
PubMed 32331932 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 36 6.41 7.04

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL4641299 1 7.04
CHEMBL4635878 1 7.02
CHEMBL4649628 1 6.96
CHEMBL4648704 1 6.86
CHEMBL4645468 1 6.83
CHEMBL4642518 1 6.80
CHEMBL4644038 1 6.80
CHEMBL4637357 1 6.80
CHEMBL4644118 1 6.73
CHEMBL4649205 1 6.73
CHEMBL4646915 1 6.71
CHEMBL4638330 1 6.66
CHEMBL4637397 1 6.58
CHEMBL4636652 1 6.52
CHEMBL4632614 1 6.46
CHEMBL4642023 1 6.44
CHEMBL4641343 1 6.42
CHEMBL4634829 1 6.41
CHEMBL4638976 1 6.39
CHEMBL4638264 1 6.39
CHEMBL4639206 1 6.38
CHEMBL4637745 1 6.34
CHEMBL4640939 1 6.31
CHEMBL4646582 1 6.29
CHEMBL4649561 1 6.21
CHEMBL4641048 1 6.20
CHEMBL4640923 1 6.15
CHEMBL4644387 1 6.14
CHEMBL4643947 1 6.13
CHEMBL4645863 1 6.12

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL4641299 IC50 = 92.0 nM 7.04
CHEMBL4635878 IC50 = 95.0 nM 7.02
CHEMBL4649628 IC50 = 109.0 nM 6.96
CHEMBL4648704 IC50 = 137.0 nM 6.86
CHEMBL4645468 IC50 = 149.0 nM 6.83
CHEMBL4642518 IC50 = 157.0 nM 6.80
CHEMBL4644038 IC50 = 160.0 nM 6.80
CHEMBL4637357 IC50 = 158.0 nM 6.80
CHEMBL4644118 IC50 = 187.0 nM 6.73
CHEMBL4649205 IC50 = 188.0 nM 6.73
CHEMBL4646915 IC50 = 197.0 nM 6.71
CHEMBL4638330 IC50 = 219.0 nM 6.66
CHEMBL4637397 IC50 = 260.0 nM 6.58
CHEMBL4636652 IC50 = 299.0 nM 6.52
CHEMBL4632614 IC50 = 351.0 nM 6.46
CHEMBL4642023 IC50 = 363.0 nM 6.44
CHEMBL4641343 IC50 = 384.0 nM 6.42
CHEMBL4634829 IC50 = 394.0 nM 6.41
CHEMBL4638976 IC50 = 404.0 nM 6.39
CHEMBL4638264 IC50 = 404.0 nM 6.39
CHEMBL4639206 IC50 = 415.0 nM 6.38
CHEMBL4637745 IC50 = 458.0 nM 6.34
CHEMBL4640939 IC50 = 490.0 nM 6.31
CHEMBL4646582 IC50 = 518.0 nM 6.29
CHEMBL4649561 IC50 = 618.0 nM 6.21
CHEMBL4641048 IC50 = 631.0 nM 6.20
CHEMBL4640923 IC50 = 709.0 nM 6.15
CHEMBL4644387 IC50 = 726.0 nM 6.14
CHEMBL4643947 IC50 = 744.0 nM 6.13
CHEMBL4645863 IC50 = 759.0 nM 6.12
CHEMBL4647014 IC50 = 972.0 nM 6.01
CHEMBL4632432 IC50 = 1107.0 nM 5.96
CHEMBL4636123 IC50 = 1169.0 nM 5.93
CHEMBL4644657 IC50 = 1169.0 nM 5.93
CHEMBL4633758 IC50 = 1506.0 nM 5.82
CHEMBL4645825 IC50 = 3580.0 nM 5.45