Assay Detail
Binding
CHEMBL4623430
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Binding affinity to RORbeta (unknown origin) assessed as dissociation constant by thermal shift binding assay
23
Total Activities
23
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Discovery and optimization of new oxadiazole substituted thiazole RORγt inverse agonists through a bioisosteric amide replacement approach.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Kd | 23 | 5.80 | 7.21 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4642674 | — | — | 1 | 7.21 |
| CHEMBL4647899 | — | — | 1 | 6.94 |
| CHEMBL4645288 | — | — | 1 | 6.32 |
| CHEMBL4641039 | — | — | 1 | 6.17 |
| CHEMBL4633899 | — | — | 1 | 6.08 |
| CHEMBL4637003 | — | — | 1 | 6.02 |
| CHEMBL4632527 | — | — | 1 | 6.00 |
| CHEMBL4635823 | — | — | 1 | 5.95 |
| CHEMBL4649094 | — | — | 1 | 5.81 |
| CHEMBL4647734 | — | — | 1 | 5.79 |
| CHEMBL4641138 | — | — | 1 | 5.58 |
| CHEMBL4634072 | — | — | 1 | 5.53 |
| CHEMBL4633325 | — | — | 1 | 5.49 |
| CHEMBL4637144 | — | — | 1 | 5.35 |
| CHEMBL4642631 | — | — | 1 | 5.28 |
| CHEMBL4649427 | — | — | 1 | 5.01 |
| CHEMBL4642733 | — | — | 1 | 4.97 |
| CHEMBL4649863 | — | — | 1 | 4.85 |
| CHEMBL4649210 | — | — | 1 | - |
| CHEMBL4645942 | — | — | 1 | - |
| CHEMBL4648849 | — | — | 1 | - |
| CHEMBL4644116 | — | — | 1 | - |
| CHEMBL4634974 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4642674 | — | Kd | = | 62.0 | nM | 7.21 |
| CHEMBL4647899 | — | Kd | = | 115.0 | nM | 6.94 |
| CHEMBL4645288 | — | Kd | = | 474.0 | nM | 6.32 |
| CHEMBL4641039 | — | Kd | = | 675.0 | nM | 6.17 |
| CHEMBL4633899 | — | Kd | = | 831.0 | nM | 6.08 |
| CHEMBL4637003 | — | Kd | = | 949.0 | nM | 6.02 |
| CHEMBL4632527 | — | Kd | = | 1000.0 | nM | 6.00 |
| CHEMBL4635823 | — | Kd | = | 1121.0 | nM | 5.95 |
| CHEMBL4649094 | — | Kd | = | 1555.0 | nM | 5.81 |
| CHEMBL4647734 | — | Kd | = | 1613.0 | nM | 5.79 |
| CHEMBL4641138 | — | Kd | = | 2612.0 | nM | 5.58 |
| CHEMBL4634072 | — | Kd | = | 2955.0 | nM | 5.53 |
| CHEMBL4633325 | — | Kd | = | 3236.0 | nM | 5.49 |
| CHEMBL4637144 | — | Kd | = | 4484.0 | nM | 5.35 |
| CHEMBL4642631 | — | Kd | = | 5259.0 | nM | 5.28 |
| CHEMBL4649427 | — | Kd | = | 9780.0 | nM | 5.01 |
| CHEMBL4642733 | — | Kd | = | 10629.0 | nM | 4.97 |
| CHEMBL4649863 | — | Kd | = | 14090.0 | nM | 4.85 |
| CHEMBL4649210 | — | Kd | - | — | - | |
| CHEMBL4645942 | — | Kd | - | — | - | |
| CHEMBL4648849 | — | Kd | > | 60000.0 | nM | - |
| CHEMBL4644116 | — | Kd | > | 50000.0 | nM | - |
| CHEMBL4634974 | — | Kd | > | 91000.0 | nM | - |