Assay Detail
Binding
CHEMBL4624203
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Inhibition of GARFTase in Chinese Hamster MTXRII-OuaR2-4/RFC/FRalpha/PCFT-null R2 cells assessed as reduction in cell growth after 96 hrs by Cell-Titer Blue assay
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Cricetulus griseus |
| Cell Type | R2 |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Design, synthesis and biological evaluation of novel pyrrolo[2,3-d]pyrimidine as tumor-targeting agents with selectivity for tumor uptake by high affinity folate receptors over the reduced folate carrier.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 9 | 6.16 | 6.16 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4636872 | — | — | 1 | 6.16 |
| CHEMBL192632 | — | — | 1 | - |
| CHEMBL365307 | — | — | 1 | - |
| CHEMBL4437824 | — | — | 1 | - |
| CHEMBL4645676 | — | — | 1 | - |
| CHEMBL4643623 | — | — | 1 | - |
| CHEMBL4641908 | — | — | 1 | - |
| CHEMBL4638232 | — | — | 1 | - |
| CHEMBL4642637 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4636872 | — | IC50 | = | 697.0 | nM | 6.16 |
| CHEMBL192632 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL365307 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL4437824 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL4645676 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL4643623 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL4641908 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL4638232 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL4642637 | — | IC50 | > | 1000.0 | nM | - |