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Assay Detail

CHEMBL4624361

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibition of rat intestinal sucrase
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Rattus norvegicus
Confidence 0 — Uncurated / Unknown
Curated By Autocuration

Target

Unchecked (CHEMBL612545)
Type UNCHECKED

Publication

3,4-Dihydroxyphenethyl nitrate with nitric oxide releasing, antioxidant, hypoglycemic and hypolipidemic effects.
Xie YD, Liu JP, Wang W, Shi YH, Wang XP, Sun M, Xu XY, Li N.
Bioorg Med Chem Lett (2020) 30 : 127277 -127277
PubMed 32527456 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 3 4.64 5.64

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL404271 ACARBOSE 4.0 1 5.64
CHEMBL4644322 1 4.16
CHEMBL1950045 HYDROXYTYROSOL 3.0 1 4.12

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL404271 ACARBOSE IC50 = 2310.0 nM 5.64
CHEMBL4644322 IC50 = 68730.0 nM 4.16
CHEMBL1950045 HYDROXYTYROSOL IC50 = 75100.0 nM 4.12