Assay Detail
Binding
CHEMBL4624436
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Inhibition of rabbit muscle Glycogen phosphorylase measured phosphate release from glucose-1-phosphate
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Oryctolagus cuniculus |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Synthesis, in vitro ADME profiling and in vivo pharmacological evaluation of novel glycogen phosphorylase inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 6.68 | 7.31 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4642740 | — | — | 1 | 7.31 |
| CHEMBL319136 | — | — | 1 | 7.04 |
| CHEMBL4636142 | — | — | 1 | 6.54 |
| CHEMBL4644001 | — | — | 1 | 6.26 |
| CHEMBL4635901 | — | — | 1 | 6.24 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4642740 | — | IC50 | = | 48.7 | nM | 7.31 |
| CHEMBL319136 | — | IC50 | = | 92.2 | nM | 7.04 |
| CHEMBL4636142 | — | IC50 | = | 289.4 | nM | 6.54 |
| CHEMBL4644001 | — | IC50 | = | 555.2 | nM | 6.26 |
| CHEMBL4635901 | — | IC50 | = | 578.3 | nM | 6.24 |