Assay Detail
Functional
CHEMBL4624438
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Inhibition of glycogenolysis in rat hepatocytes assessed as GCN-stimulated glycogen breakdown after 5 mins
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Rattus norvegicus |
| Cell Type | Hepatocyte |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Synthesis, in vitro ADME profiling and in vivo pharmacological evaluation of novel glycogen phosphorylase inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 5.39 | 6.14 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4642740 | — | — | 1 | 6.14 |
| CHEMBL319136 | — | — | 1 | 5.50 |
| CHEMBL4636142 | — | — | 1 | 5.15 |
| CHEMBL4644001 | — | — | 1 | 5.12 |
| CHEMBL4635901 | — | — | 1 | 5.02 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4642740 | — | IC50 | = | 719.5 | nM | 6.14 |
| CHEMBL319136 | — | IC50 | = | 3172.5 | nM | 5.50 |
| CHEMBL4636142 | — | IC50 | = | 7150.0 | nM | 5.15 |
| CHEMBL4644001 | — | IC50 | = | 7650.0 | nM | 5.12 |
| CHEMBL4635901 | — | IC50 | = | 9460.0 | nM | 5.02 |