Assay Detail
Functional
CHEMBL4624654
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Cytotoxicity against human patient derived GBM cells assessed as reduction in cell viability measured after 48 hrs by Hoechst staining based assay
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | GBM |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
PARP inhibitor cyanine dye conjugate with enhanced cytotoxic and antiproliferative activity in patient derived glioblastoma cell lines.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 3 | 6.33 | 6.89 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4645514 | — | — | 1 | 6.89 |
| CHEMBL4218804 | — | — | 1 | 5.76 |
| CHEMBL1173055 | RUCAPARIB | 4.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4645514 | — | EC50 | = | 128.0 | nM | 6.89 |
| CHEMBL4218804 | — | EC50 | = | 1735.0 | nM | 5.76 |
| CHEMBL1173055 | RUCAPARIB | EC50 | > | 100000.0 | nM | - |