Assay Detail
Functional
CHEMBL4624660
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Synergistic antiproliferative activity against human patient derived GBM cells assessed as reduction in cell proliferation measured after 48 hrs in presence of temozolomide by Edu incorporation assay
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | GBM |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
PARP inhibitor cyanine dye conjugate with enhanced cytotoxic and antiproliferative activity in patient derived glioblastoma cell lines.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 6.76 | 7.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4645514 | — | — | 1 | 7.70 |
| CHEMBL4218804 | — | — | 1 | 6.92 |
| CHEMBL1173055 | RUCAPARIB | 4.0 | 1 | 5.65 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4645514 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL4218804 | — | IC50 | = | 120.0 | nM | 6.92 |
| CHEMBL1173055 | RUCAPARIB | IC50 | = | 2262.0 | nM | 5.65 |