Assay Detail
Binding
CHEMBL4624669
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of PDE9A (unknown origin)
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A (CHEMBL3535) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Design, synthesis and evaluation of pyrazolopyrimidinone derivatives as novel PDE9A inhibitors for treatment of Alzheimer's disease.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 8.46 | 9.22 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3360415 | — | — | 1 | 9.22 |
| CHEMBL4638644 | — | — | 1 | 8.74 |
| CHEMBL4642683 | — | — | 1 | 8.70 |
| CHEMBL4640285 | — | — | 1 | 8.68 |
| CHEMBL4644757 | — | — | 1 | 8.15 |
| CHEMBL4636079 | — | — | 1 | 7.26 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3360415 | — | IC50 | = | 0.6 | nM | 9.22 |
| CHEMBL4638644 | — | IC50 | = | 1.8 | nM | 8.74 |
| CHEMBL4642683 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL4640285 | — | IC50 | = | 2.1 | nM | 8.68 |
| CHEMBL4644757 | — | IC50 | = | 7.0 | nM | 8.15 |
| CHEMBL4636079 | — | IC50 | = | 55.0 | nM | 7.26 |