Assay Detail
Functional
CHEMBL4624829
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiproliferation activity against human HepG2 cells assessed as reduction in cell viability incubated for 96 hrs by MTT assay
24
Total Activities
24
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HepG2 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Synthesis, cytotoxicity, and in vivo antitumor activity study of parthenolide semicarbazones and thiosemicarbazones.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 24 | 5.37 | 9.12 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL428647 | PACLITAXEL | 4.0 | 1 | 9.12 |
| CHEMBL4647017 | — | — | 1 | 5.76 |
| CHEMBL4649419 | — | — | 1 | 5.56 |
| CHEMBL4641878 | — | — | 1 | 5.55 |
| CHEMBL4649423 | — | — | 1 | 5.54 |
| CHEMBL4645051 | — | — | 1 | 5.49 |
| CHEMBL4642396 | — | — | 1 | 5.48 |
| CHEMBL4633371 | — | — | 1 | 5.44 |
| CHEMBL4636438 | — | — | 1 | 5.42 |
| CHEMBL561183 | — | — | 1 | 5.32 |
| CHEMBL4634484 | — | — | 1 | 5.32 |
| CHEMBL477923 | — | — | 1 | 5.24 |
| CHEMBL4646810 | — | — | 1 | 5.23 |
| CHEMBL4633648 | — | — | 1 | 5.21 |
| CHEMBL4643037 | — | — | 1 | 5.18 |
| CHEMBL4647700 | — | — | 1 | 5.13 |
| CHEMBL4637814 | — | — | 1 | 5.13 |
| CHEMBL4638757 | — | — | 1 | 5.05 |
| CHEMBL4644332 | — | — | 1 | 4.83 |
| CHEMBL4643992 | — | — | 1 | 4.77 |
| CHEMBL4646929 | — | — | 1 | 4.77 |
| CHEMBL4641440 | — | — | 1 | 4.76 |
| CHEMBL4641992 | — | — | 1 | 4.76 |
| CHEMBL4634155 | — | — | 1 | 4.74 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL428647 | PACLITAXEL | IC50 | = | 0.762 | nM | 9.12 |
| CHEMBL4647017 | — | IC50 | = | 1740.0 | nM | 5.76 |
| CHEMBL4649419 | — | IC50 | = | 2770.0 | nM | 5.56 |
| CHEMBL4641878 | — | IC50 | = | 2830.0 | nM | 5.55 |
| CHEMBL4649423 | — | IC50 | = | 2860.0 | nM | 5.54 |
| CHEMBL4645051 | — | IC50 | = | 3230.0 | nM | 5.49 |
| CHEMBL4642396 | — | IC50 | = | 3330.0 | nM | 5.48 |
| CHEMBL4633371 | — | IC50 | = | 3660.0 | nM | 5.44 |
| CHEMBL4636438 | — | IC50 | = | 3770.0 | nM | 5.42 |
| CHEMBL561183 | — | IC50 | = | 4770.0 | nM | 5.32 |
| CHEMBL4634484 | — | IC50 | = | 4750.0 | nM | 5.32 |
| CHEMBL477923 | — | IC50 | = | 5710.0 | nM | 5.24 |
| CHEMBL4646810 | — | IC50 | = | 5880.0 | nM | 5.23 |
| CHEMBL4633648 | — | IC50 | = | 6150.0 | nM | 5.21 |
| CHEMBL4643037 | — | IC50 | = | 6540.0 | nM | 5.18 |
| CHEMBL4647700 | — | IC50 | = | 7330.0 | nM | 5.13 |
| CHEMBL4637814 | — | IC50 | = | 7430.0 | nM | 5.13 |
| CHEMBL4638757 | — | IC50 | = | 8990.0 | nM | 5.05 |
| CHEMBL4644332 | — | IC50 | = | 14860.0 | nM | 4.83 |
| CHEMBL4643992 | — | IC50 | = | 17150.0 | nM | 4.77 |
| CHEMBL4646929 | — | IC50 | = | 16820.0 | nM | 4.77 |
| CHEMBL4641440 | — | IC50 | = | 17250.0 | nM | 4.76 |
| CHEMBL4641992 | — | IC50 | = | 17440.0 | nM | 4.76 |
| CHEMBL4634155 | — | IC50 | = | 18310.0 | nM | 4.74 |