Assay Detail
Functional
CHEMBL4625192
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of LPS-induced TNFalpha release in human PBMC cells
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | PBMC |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Discovery of the potent non-steroidal glucocorticoid receptor modulator BAY 1003803 as clinical candidate.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 8.96 | 9.64 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1201362 | CLOBETASOL | 3.0 | 1 | 9.64 |
| CHEMBL4638643 | — | — | 1 | 9.04 |
| CHEMBL384467 | DEXAMETHASONE | 4.0 | 1 | 8.19 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1201362 | CLOBETASOL | IC50 | = | 0.23 | nM | 9.64 |
| CHEMBL4638643 | — | IC50 | = | 0.92 | nM | 9.04 |
| CHEMBL384467 | DEXAMETHASONE | IC50 | = | 6.4 | nM | 8.19 |