Assay Detail
Functional
CHEMBL4625196
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Inhibition of PHA-induced IL2 release in human PBMC cells
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | PBMC |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Discovery of the potent non-steroidal glucocorticoid receptor modulator BAY 1003803 as clinical candidate.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 9.08 | 9.85 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1201362 | CLOBETASOL | 3.0 | 1 | 9.85 |
| CHEMBL4638643 | — | — | 1 | 9.06 |
| CHEMBL384467 | DEXAMETHASONE | 4.0 | 1 | 8.34 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1201362 | CLOBETASOL | IC50 | = | 0.14 | nM | 9.85 |
| CHEMBL4638643 | — | IC50 | = | 0.88 | nM | 9.06 |
| CHEMBL384467 | DEXAMETHASONE | IC50 | = | 4.6 | nM | 8.34 |