Assay Detail
Binding
CHEMBL4625527
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Displacement of [3H]-N-Methylspiperone from dopamine D3 receptor (unknown origin) incubated for 90 mins by microbeta counting method
6
Total Activities
5
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Structural manipulation of aporphines via C10 nitrogenation leads to the identification of new 5-HT<sub>7A</sub>R ligands.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 5 | 6.66 | 8.93 |
| Inhibition | 1 | - | - |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL20734 | NEMONAPRIDE | 2.0 | 1 | 8.93 |
| CHEMBL4641502 | — | — | 1 | 6.42 |
| CHEMBL4633042 | — | — | 1 | 5.68 |
| CHEMBL4636148 | — | — | 1 | 5.61 |
| CHEMBL4633786 | — | — | 2 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL20734 | NEMONAPRIDE | Ki | = | 1.18 | nM | 8.93 |
| CHEMBL4641502 | — | Ki | = | 381.0 | nM | 6.42 |
| CHEMBL4633042 | — | Ki | = | 2110.0 | nM | 5.68 |
| CHEMBL4636148 | — | Ki | = | 2460.0 | nM | 5.61 |
| CHEMBL4633786 | — | Ki | - | — | - | |
| CHEMBL4633786 | — | Inhibition | < | 50.0 | % | - |