Assay Detail
Functional
CHEMBL4625699
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Antiproliferative activity against human HeLa cells assessed as reduction in cell viability preincubated for 12 hrs followed by 4 Gy irradiation and measured after 60 hrs by MTT assay
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HeLa |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Designing Dihydrofolate Reductase Inhibitors as X-ray Radiosensitizers to Reverse Radioresistance of Cervical Cancer.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 5.47 | 6.19 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4641198 | — | — | 1 | 6.19 |
| CHEMBL34259 | METHOTREXATE | 4.0 | 1 | 6.09 |
| CHEMBL4647373 | — | — | 1 | 5.64 |
| CHEMBL4635593 | — | — | 1 | 5.20 |
| CHEMBL4644558 | — | — | 1 | 4.84 |
| CHEMBL48296 | — | — | 1 | 4.83 |
| CHEMBL4639534 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4641198 | — | IC50 | = | 640.0 | nM | 6.19 |
| CHEMBL34259 | METHOTREXATE | IC50 | = | 820.0 | nM | 6.09 |
| CHEMBL4647373 | — | IC50 | = | 2300.0 | nM | 5.64 |
| CHEMBL4635593 | — | IC50 | = | 6300.0 | nM | 5.20 |
| CHEMBL4644558 | — | IC50 | = | 14600.0 | nM | 4.84 |
| CHEMBL48296 | — | IC50 | = | 14800.0 | nM | 4.83 |
| CHEMBL4639534 | — | IC50 | > | 80000.0 | nM | - |