Assay Detail
Binding
CHEMBL4625802
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Inhibition of full length human recombinant FLAG-tagged HDAC2 expressed in baculovirus infected Sf9 cells using FLUOR DE LYS as substrate preincubated for 3 hrs followed by substrate addition and measured after 60 mins by fluorescence based assay
18
Total Activities
18
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | Sf9 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Selective Class I HDAC Inhibitors Based on Aryl Ketone Zinc Binding Induce HIV-1 Protein for Clearance.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 18 | 7.29 | 9.33 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4641682 | — | — | 1 | 9.33 |
| CHEMBL4637689 | — | — | 1 | 9.12 |
| CHEMBL4634501 | — | — | 1 | 9.09 |
| CHEMBL4632775 | — | — | 1 | 8.15 |
| CHEMBL4644307 | — | — | 1 | 8.07 |
| CHEMBL4637836 | — | — | 1 | 7.68 |
| CHEMBL4647458 | — | — | 1 | 7.62 |
| CHEMBL4633968 | — | — | 1 | 7.30 |
| CHEMBL4632449 | — | — | 1 | 7.21 |
| CHEMBL4644721 | — | — | 1 | 7.09 |
| CHEMBL4641904 | — | — | 1 | 7.07 |
| CHEMBL4647164 | — | — | 1 | 7.00 |
| CHEMBL4649382 | — | — | 1 | 6.62 |
| CHEMBL4646763 | — | — | 1 | 6.33 |
| CHEMBL4644575 | — | — | 1 | 6.16 |
| CHEMBL4636534 | — | — | 1 | 6.13 |
| CHEMBL4639586 | — | — | 1 | 5.89 |
| CHEMBL4635130 | — | — | 1 | 5.31 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4641682 | — | IC50 | = | 0.47 | nM | 9.33 |
| CHEMBL4637689 | — | IC50 | = | 0.76 | nM | 9.12 |
| CHEMBL4634501 | — | IC50 | = | 0.82 | nM | 9.09 |
| CHEMBL4632775 | — | IC50 | = | 7.1 | nM | 8.15 |
| CHEMBL4644307 | — | IC50 | = | 8.5 | nM | 8.07 |
| CHEMBL4637836 | — | IC50 | = | 21.0 | nM | 7.68 |
| CHEMBL4647458 | — | IC50 | = | 24.0 | nM | 7.62 |
| CHEMBL4633968 | — | IC50 | = | 50.0 | nM | 7.30 |
| CHEMBL4632449 | — | IC50 | = | 61.0 | nM | 7.21 |
| CHEMBL4644721 | — | IC50 | = | 81.0 | nM | 7.09 |
| CHEMBL4641904 | — | IC50 | = | 86.0 | nM | 7.07 |
| CHEMBL4647164 | — | IC50 | = | 101.0 | nM | 7.00 |
| CHEMBL4649382 | — | IC50 | = | 240.0 | nM | 6.62 |
| CHEMBL4646763 | — | IC50 | = | 470.0 | nM | 6.33 |
| CHEMBL4644575 | — | IC50 | = | 700.0 | nM | 6.16 |
| CHEMBL4636534 | — | IC50 | = | 740.0 | nM | 6.13 |
| CHEMBL4639586 | — | IC50 | = | 1300.0 | nM | 5.89 |
| CHEMBL4635130 | — | IC50 | = | 4900.0 | nM | 5.31 |