Assay Detail
Binding
CHEMBL4625805
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Inhibition of human recombinant HDAC8 expressed in Escherichia coli using FLUOR DE LYS as substrate preincubated for 3 hrs followed by substrate addition and measured after 60 mins by fluorescence based assay
18
Total Activities
18
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Selective Class I HDAC Inhibitors Based on Aryl Ketone Zinc Binding Induce HIV-1 Protein for Clearance.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 18 | 6.65 | 8.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4641682 | — | — | 1 | 8.52 |
| CHEMBL4637689 | — | — | 1 | 7.80 |
| CHEMBL4634501 | — | — | 1 | 7.50 |
| CHEMBL4632775 | — | — | 1 | 7.00 |
| CHEMBL4641904 | — | — | 1 | 6.67 |
| CHEMBL4644307 | — | — | 1 | 6.55 |
| CHEMBL4647458 | — | — | 1 | 6.42 |
| CHEMBL4644721 | — | — | 1 | 6.35 |
| CHEMBL4632449 | — | — | 1 | 6.33 |
| CHEMBL4637836 | — | — | 1 | 6.22 |
| CHEMBL4639586 | — | — | 1 | 5.30 |
| CHEMBL4633968 | — | — | 1 | 5.10 |
| CHEMBL4647164 | — | — | 1 | - |
| CHEMBL4646763 | — | — | 1 | - |
| CHEMBL4635130 | — | — | 1 | - |
| CHEMBL4644575 | — | — | 1 | - |
| CHEMBL4636534 | — | — | 1 | - |
| CHEMBL4649382 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4641682 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL4637689 | — | IC50 | = | 16.0 | nM | 7.80 |
| CHEMBL4634501 | — | IC50 | = | 32.0 | nM | 7.50 |
| CHEMBL4632775 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL4641904 | — | IC50 | = | 212.0 | nM | 6.67 |
| CHEMBL4644307 | — | IC50 | = | 280.0 | nM | 6.55 |
| CHEMBL4647458 | — | IC50 | = | 380.0 | nM | 6.42 |
| CHEMBL4644721 | — | IC50 | = | 445.0 | nM | 6.35 |
| CHEMBL4632449 | — | IC50 | = | 466.0 | nM | 6.33 |
| CHEMBL4637836 | — | IC50 | = | 603.0 | nM | 6.22 |
| CHEMBL4639586 | — | IC50 | = | 5000.0 | nM | 5.30 |
| CHEMBL4633968 | — | IC50 | = | 8000.0 | nM | 5.10 |
| CHEMBL4647164 | — | IC50 | > | 900.0 | nM | - |
| CHEMBL4646763 | — | IC50 | - | — | - | |
| CHEMBL4635130 | — | IC50 | - | — | - | |
| CHEMBL4644575 | — | IC50 | - | — | - | |
| CHEMBL4636534 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL4649382 | — | IC50 | - | — | - |