Assay Detail
ADMET
CHEMBL4626294
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Inhibition of SHP2 (unknown origin) expressed in Escherichia coli BL21 using p-nitrophenyl phosphate as substrate measured after 30 mins by UV-vis spectrophotometric method
36
Total Activities
36
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | ADMET |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Tyrosine-protein phosphatase non-receptor type 11 (CHEMBL3864) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Highly Potent and Selective <i>N</i>-Aryl Oxamic Acid-Based Inhibitors for <i>Mycobacterium tuberculosis</i> Protein Tyrosine Phosphatase B.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 36 | 4.47 | 4.97 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4641106 | — | — | 1 | 4.97 |
| CHEMBL4637373 | — | — | 1 | 4.82 |
| CHEMBL4635765 | — | — | 1 | 4.82 |
| CHEMBL4647032 | — | — | 1 | 4.56 |
| CHEMBL4642395 | — | — | 1 | 4.54 |
| CHEMBL4644874 | — | — | 1 | 4.35 |
| CHEMBL4632818 | — | — | 1 | 4.32 |
| CHEMBL4633958 | — | — | 1 | 4.28 |
| CHEMBL4633719 | — | — | 1 | 4.24 |
| CHEMBL4649025 | — | — | 1 | 4.16 |
| CHEMBL4636357 | — | — | 1 | 4.11 |
| CHEMBL4649291 | — | — | 1 | - |
| CHEMBL4635176 | — | — | 1 | - |
| CHEMBL4640123 | — | — | 1 | - |
| CHEMBL4646506 | — | — | 1 | - |
| CHEMBL4647367 | — | — | 1 | - |
| CHEMBL4632655 | — | — | 1 | - |
| CHEMBL4645770 | — | — | 1 | - |
| CHEMBL4636548 | — | — | 1 | - |
| CHEMBL4649112 | — | — | 1 | - |
| CHEMBL4641525 | — | — | 1 | - |
| CHEMBL4632681 | — | — | 1 | - |
| CHEMBL4633441 | — | — | 1 | - |
| CHEMBL4647989 | — | — | 1 | - |
| CHEMBL3248231 | — | — | 1 | - |
| CHEMBL4649133 | — | — | 1 | - |
| CHEMBL4635310 | — | — | 1 | - |
| CHEMBL4638797 | — | — | 1 | - |
| CHEMBL4636634 | — | — | 1 | - |
| CHEMBL4638011 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4641106 | — | IC50 | = | 10600.0 | nM | 4.97 |
| CHEMBL4637373 | — | IC50 | = | 15200.0 | nM | 4.82 |
| CHEMBL4635765 | — | IC50 | = | 15300.0 | nM | 4.82 |
| CHEMBL4647032 | — | IC50 | = | 27300.0 | nM | 4.56 |
| CHEMBL4642395 | — | IC50 | = | 29000.0 | nM | 4.54 |
| CHEMBL4644874 | — | IC50 | = | 44500.0 | nM | 4.35 |
| CHEMBL4632818 | — | IC50 | = | 47500.0 | nM | 4.32 |
| CHEMBL4633958 | — | IC50 | = | 52600.0 | nM | 4.28 |
| CHEMBL4633719 | — | IC50 | = | 58000.0 | nM | 4.24 |
| CHEMBL4649025 | — | IC50 | = | 69000.0 | nM | 4.16 |
| CHEMBL4636357 | — | IC50 | = | 78500.0 | nM | 4.11 |
| CHEMBL4632655 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL4647367 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL4646506 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL4640123 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL4635176 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL4649291 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL4649843 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL4649071 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL4642274 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL4637459 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL4647377 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL4649838 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL4645770 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL4636548 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL4649112 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL4641525 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL4632681 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL4633441 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL4647989 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL3248231 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL4649133 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL4635310 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL4638797 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL4636634 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL4638011 | — | IC50 | > | 30000.0 | nM | - |