Assay Detail
Binding
CHEMBL4626319
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Competitive inhibition of Mycobacterium tuberculosis PTPB expressed in Escherichia coli BL21 (DE3) using varying levels of p-nitrophenyl phosphate as substrate measured after 30 mins by Lineweaver-Burk plot analysis
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Mycobacterium tuberculosis |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Phosphotyrosine protein phosphatase (CHEMBL4295521) ↗| Type | SINGLE PROTEIN |
| Organism | Mycobacterium tuberculosis |
Publication
Highly Potent and Selective <i>N</i>-Aryl Oxamic Acid-Based Inhibitors for <i>Mycobacterium tuberculosis</i> Protein Tyrosine Phosphatase B.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 3 | 8.60 | 8.92 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4637373 | — | — | 1 | 8.92 |
| CHEMBL4647367 | — | — | 1 | 8.57 |
| CHEMBL4638011 | — | — | 1 | 8.31 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4637373 | — | Ki | = | 1.2 | nM | 8.92 |
| CHEMBL4647367 | — | Ki | = | 2.7 | nM | 8.57 |
| CHEMBL4638011 | — | Ki | = | 4.9 | nM | 8.31 |