Assay Detail
Binding
CHEMBL4626322
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of Mycobacterium tuberculosis PTPB I203A mutant expressed in Escherichia coli BL21 (DE3) using p-nitrophenyl phosphate as substrate measured after 30 mins by UV-vis spectrophotometric method
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Mycobacterium tuberculosis |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Phosphotyrosine protein phosphatase (CHEMBL4295521) ↗| Type | SINGLE PROTEIN |
| Organism | Mycobacterium tuberculosis |
Publication
Highly Potent and Selective <i>N</i>-Aryl Oxamic Acid-Based Inhibitors for <i>Mycobacterium tuberculosis</i> Protein Tyrosine Phosphatase B.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 7.51 | 7.68 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4637373 | — | — | 1 | 7.68 |
| CHEMBL4647367 | — | — | 1 | 7.60 |
| CHEMBL4638011 | — | — | 1 | 7.40 |
| CHEMBL4637459 | — | — | 1 | 7.37 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4637373 | — | IC50 | = | 21.0 | nM | 7.68 |
| CHEMBL4647367 | — | IC50 | = | 25.0 | nM | 7.60 |
| CHEMBL4638011 | — | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL4637459 | — | IC50 | = | 43.0 | nM | 7.37 |