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Assay Detail

CHEMBL4626519

Review assay metadata, readout intent, target linkage, and publication context from the same page.

ADMET
Inhibition of SCD in human H2009 cells non-expressing CYP4F11 assessed as reduction in cell viability incubated for 96 hrs by cell titer Glo reagent based assay
36
Total Activities
36
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type ADMET
Organism Homo sapiens
Confidence 9 — Direct single protein target
Curated By Autocuration

Target

Stearoyl-CoA desaturase (CHEMBL5555)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Tumor-Activated Benzothiazole Inhibitors of Stearoyl-CoA Desaturase.
Williams NS, Gonzales S, Naidoo J, Rivera-Cancel G, Voruganti S, Mallipeddi P, Theodoropoulos PC, Geboers S, Chen H, Ortiz F, Posner B, Nijhawan D, Ready JM.
J Med Chem (2020) 63 : 9773 -9786
PubMed 32787093 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 36 5.36 7.30

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL4640865 1 7.30
CHEMBL4641073 1 7.22
CHEMBL4641731 1 7.05
CHEMBL4648314 1 6.00
CHEMBL4640424 1 5.96
CHEMBL4648170 1 5.75
CHEMBL4636605 1 5.70
CHEMBL4632656 1 5.62
CHEMBL4648521 1 5.55
CHEMBL4638796 1 5.50
CHEMBL4643765 1 5.30
CHEMBL499832 1 5.26
CHEMBL4636558 1 5.24
CHEMBL4646942 1 5.16
CHEMBL4633256 1 5.05
CHEMBL4643747 1 4.83
CHEMBL4639169 1 4.77
CHEMBL213306 1 4.68
CHEMBL4633446 1 4.68
CHEMBL4637153 1 4.66
CHEMBL4641864 1 4.66
CHEMBL1380535 1 4.60
CHEMBL4644536 1 4.60
CHEMBL1529450 1 4.51
CHEMBL4636108 1 4.43
CHEMBL4638890 1 -
CHEMBL1350929 1 -
CHEMBL4642949 1 -
CHEMBL4636689 1 -
CHEMBL4641596 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL4640865 IC50 = 50.0 nM 7.30
CHEMBL4641073 IC50 = 60.0 nM 7.22
CHEMBL4641731 IC50 = 90.0 nM 7.05
CHEMBL4648314 IC50 = 1000.0 nM 6.00
CHEMBL4640424 IC50 = 1100.0 nM 5.96
CHEMBL4648170 IC50 = 1800.0 nM 5.75
CHEMBL4636605 IC50 = 2000.0 nM 5.70
CHEMBL4632656 IC50 = 2400.0 nM 5.62
CHEMBL4648521 IC50 = 2800.0 nM 5.55
CHEMBL4638796 IC50 = 3200.0 nM 5.50
CHEMBL4643765 IC50 = 5000.0 nM 5.30
CHEMBL499832 IC50 = 5500.0 nM 5.26
CHEMBL4636558 IC50 = 5700.0 nM 5.24
CHEMBL4646942 IC50 = 6900.0 nM 5.16
CHEMBL4633256 IC50 = 8900.0 nM 5.05
CHEMBL4643747 IC50 = 14900.0 nM 4.83
CHEMBL4639169 IC50 = 17000.0 nM 4.77
CHEMBL4633446 IC50 = 21000.0 nM 4.68
CHEMBL213306 IC50 = 21000.0 nM 4.68
CHEMBL4637153 IC50 = 22000.0 nM 4.66
CHEMBL4641864 IC50 = 22000.0 nM 4.66
CHEMBL1380535 IC50 = 25000.0 nM 4.60
CHEMBL4644536 IC50 = 25000.0 nM 4.60
CHEMBL1529450 IC50 = 31000.0 nM 4.51
CHEMBL4636108 IC50 = 37000.0 nM 4.43
CHEMBL4645882 IC50 > 50000.0 nM -
CHEMBL4649153 IC50 > 50000.0 nM -
CHEMBL4648961 IC50 > 50000.0 nM -
CHEMBL4635316 IC50 > 50000.0 nM -
CHEMBL4633867 IC50 > 50000.0 nM -
CHEMBL4641007 IC50 >= 1100.0 nM -
CHEMBL4641596 IC50 > 50000.0 nM -
CHEMBL4636689 IC50 > 50000.0 nM -
CHEMBL4642949 IC50 > 50000.0 nM -
CHEMBL1350929 IC50 > 50000.0 nM -
CHEMBL4638890 IC50 > 50000.0 nM -