Assay Detail
Functional
CHEMBL4626580
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Antiviral activity against Victoria lineage of Influenza B virus (B/Brisbane/60/2008) infected in MDCK cells assessed as protection against virus-induced cell death measured 72 to 96 hrs post-infection by CellTiter-Glo assay
3
Total Activities
3
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Influenza B virus |
| Cell Type | MDCK |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Non-rigid Diarylmethyl Analogs of Baloxavir as Cap-Dependent Endonuclease Inhibitors of Influenza Viruses.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 2 | 5.29 | 5.29 |
| Activity | 1 | - | - |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4645810 | — | — | 1 | 5.29 |
| CHEMBL4632885 | — | — | 1 | 5.29 |
| CHEMBL4297215 | BALOXAVIR | 2.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4645810 | — | EC50 | = | 5100.0 | nM | 5.29 |
| CHEMBL4632885 | — | EC50 | = | 5100.0 | nM | 5.29 |
| CHEMBL4297215 | BALOXAVIR | Activity | - | — | - |