Assay Detail
Functional
CHEMBL4626974
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Growth inhibition of human MV4-11 cells incubated for 72 hrs by Cell-titre glo assay
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | MV4-11 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Structure-Based Design of a Bromodomain and Extraterminal Domain (BET) Inhibitor Selective for the N-Terminal Bromodomains That Retains an Anti-inflammatory and Antiproliferative Phenotype.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 6.90 | 7.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4639128 | GSK778 | — | 1 | 7.00 |
| CHEMBL2017291 | — | — | 1 | 7.00 |
| CHEMBL4638144 | — | — | 1 | 6.70 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4639128 | GSK778 | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL2017291 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL4638144 | — | IC50 | = | 199.53 | nM | 6.70 |