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Assay Detail

CHEMBL4627601

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Antiproliferative activity against over expressing E2H2 human WSU-DLCL2 cells
28
Total Activities
28
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Homo sapiens
Confidence 0 — Uncurated / Unknown
Curated By Autocuration

Target

Unchecked (CHEMBL612545)
Type UNCHECKED

Publication

Design and synthesis of (E)-1,2-diphenylethene-based EZH2 inhibitors.
He H, Hu X, Teng F, Liu Z, Zhang Q, Feng Z, Feng Q, Yu L.
Bioorg Med Chem Lett (2020) 30 : 126957 -126957
PubMed 31959420 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 28 5.06 5.79

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL4645357 1 5.79
CHEMBL4637350 1 5.79
CHEMBL4647553 1 5.59
CHEMBL4643350 1 5.51
CHEMBL4633092 1 5.34
CHEMBL4645766 1 5.23
CHEMBL4649585 1 5.21
CHEMBL4643252 1 5.03
CHEMBL4633751 1 4.90
CHEMBL4635610 1 4.76
CHEMBL3414621 TAZEMETOSTAT 4.0 1 4.75
CHEMBL4645331 1 4.68
CHEMBL4645698 1 4.67
CHEMBL4634950 1 4.59
CHEMBL4646490 1 4.56
CHEMBL4636556 1 4.56
CHEMBL4646348 1 -
CHEMBL4644018 1 -
CHEMBL4637305 1 -
CHEMBL4646766 1 -
CHEMBL4640284 1 -
CHEMBL4642615 1 -
CHEMBL4639968 1 -
CHEMBL4646692 1 -
CHEMBL4644328 1 -
CHEMBL4638443 1 -
CHEMBL4646059 1 -
CHEMBL4635261 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL4645357 IC50 = 1610.0 nM 5.79
CHEMBL4637350 IC50 = 1640.0 nM 5.79
CHEMBL4647553 IC50 = 2580.0 nM 5.59
CHEMBL4643350 IC50 = 3110.0 nM 5.51
CHEMBL4633092 IC50 = 4580.0 nM 5.34
CHEMBL4645766 IC50 = 5850.0 nM 5.23
CHEMBL4649585 IC50 = 6180.0 nM 5.21
CHEMBL4643252 IC50 = 9270.0 nM 5.03
CHEMBL4633751 IC50 = 12610.0 nM 4.90
CHEMBL4635610 IC50 = 17540.0 nM 4.76
CHEMBL3414621 TAZEMETOSTAT IC50 = 17790.0 nM 4.75
CHEMBL4645331 IC50 = 20930.0 nM 4.68
CHEMBL4645698 IC50 = 21250.0 nM 4.67
CHEMBL4634950 IC50 = 25800.0 nM 4.59
CHEMBL4646490 IC50 = 27670.0 nM 4.56
CHEMBL4636556 IC50 = 27700.0 nM 4.56
CHEMBL4646348 IC50 - -
CHEMBL4644018 IC50 > 30000.0 nM -
CHEMBL4637305 IC50 > 30000.0 nM -
CHEMBL4646766 IC50 > 30000.0 nM -
CHEMBL4640284 IC50 > 30000.0 nM -
CHEMBL4642615 IC50 > 30000.0 nM -
CHEMBL4639968 IC50 > 30000.0 nM -
CHEMBL4646692 IC50 > 30000.0 nM -
CHEMBL4644328 IC50 > 30000.0 nM -
CHEMBL4638443 IC50 > 30000.0 nM -
CHEMBL4646059 IC50 > 30000.0 nM -
CHEMBL4635261 IC50 > 30000.0 nM -