Assay Detail
Binding
CHEMBL4628104
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Inhibition of human recombinant HDAC1 using fluorogenic HDAC substrate preincubated for 30 mins followed by substrate addition and measured after 15 mins by fluorogenic assay
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Pyrimethamine conjugated histone deacetylase inhibitors: Design, synthesis and evidence for triple negative breast cancer selective cytotoxicity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 6.51 | 7.38 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL98 | VORINOSTAT | 4.0 | 1 | 7.38 |
| CHEMBL4635479 | — | — | 1 | 7.35 |
| CHEMBL4636452 | — | — | 1 | 6.68 |
| CHEMBL4649487 | — | — | 1 | 6.58 |
| CHEMBL4633409 | — | — | 1 | 5.66 |
| CHEMBL4634096 | — | — | 1 | 5.43 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL98 | VORINOSTAT | IC50 | = | 42.0 | nM | 7.38 |
| CHEMBL4635479 | — | IC50 | = | 45.0 | nM | 7.35 |
| CHEMBL4636452 | — | IC50 | = | 210.0 | nM | 6.68 |
| CHEMBL4649487 | — | IC50 | = | 260.0 | nM | 6.58 |
| CHEMBL4633409 | — | IC50 | = | 2200.0 | nM | 5.66 |
| CHEMBL4634096 | — | IC50 | = | 3700.0 | nM | 5.43 |