Assay Detail
Functional
CHEMBL4628107
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Antiproliferative activity in human A549 cells assessed as inhibition of cell viability after 72 hrs by MTS assay
8
Total Activities
8
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | A549 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Pyrimethamine conjugated histone deacetylase inhibitors: Design, synthesis and evidence for triple negative breast cancer selective cytotoxicity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 4.51 | 5.00 |
| Inhibition | 3 | - | - |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4634096 | — | — | 1 | 5.00 |
| CHEMBL98 | VORINOSTAT | 4.0 | 1 | 4.80 |
| CHEMBL4635479 | — | — | 1 | 4.18 |
| CHEMBL4636452 | — | — | 1 | 4.05 |
| CHEMBL4649487 | — | — | 1 | - |
| CHEMBL4648403 | — | — | 1 | - |
| CHEMBL4633409 | — | — | 1 | - |
| CHEMBL36 | PYRIMETHAMINE | 4.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4634096 | — | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL98 | VORINOSTAT | IC50 | = | 15730.0 | nM | 4.80 |
| CHEMBL4635479 | — | IC50 | = | 65490.0 | nM | 4.18 |
| CHEMBL4636452 | — | IC50 | = | 88460.0 | nM | 4.05 |
| CHEMBL4649487 | — | Inhibition | - | % | - | |
| CHEMBL4648403 | — | IC50 | = | 113750.0 | nM | - |
| CHEMBL4633409 | — | Inhibition | - | % | - | |
| CHEMBL36 | PYRIMETHAMINE | Inhibition | - | % | - |