Assay Detail
Binding
CHEMBL4628141
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Non-nucleoside inhibition of NS5B polymerase in HCV genotype 1b by Taqman probe based RT-PCR analysis
25
Total Activities
25
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Hepatitis C virus subtype 1b |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Target
RNA-directed RNA polymerase (CHEMBL4296320) ↗| Type | SINGLE PROTEIN |
| Organism | Hepacivirus hominis |
Publication
Multi-step parallel synthesis enabled optimization of benzofuran derivatives as pan-genotypic non-nucleoside inhibitors of HCV NS5B.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 25 | 8.61 | 9.10 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4641600 | — | — | 1 | 9.10 |
| CHEMBL4645241 | — | — | 1 | 8.96 |
| CHEMBL4644026 | — | — | 1 | 8.96 |
| CHEMBL3961836 | — | — | 1 | 8.96 |
| CHEMBL3955887 | — | — | 1 | 8.89 |
| CHEMBL4643882 | — | — | 1 | 8.82 |
| CHEMBL3925436 | — | — | 1 | 8.80 |
| CHEMBL3961240 | — | — | 1 | 8.80 |
| CHEMBL3931672 | MK-8876 | 1.0 | 1 | 8.66 |
| CHEMBL3930991 | — | — | 1 | 8.62 |
| CHEMBL4115427 | — | — | 1 | 8.59 |
| CHEMBL4648683 | — | — | 1 | 8.59 |
| CHEMBL3964459 | — | — | 1 | 8.57 |
| CHEMBL3942127 | — | — | 1 | 8.57 |
| CHEMBL3958500 | — | — | 1 | 8.55 |
| CHEMBL4636179 | — | — | 1 | 8.54 |
| CHEMBL3978278 | — | — | 1 | 8.48 |
| CHEMBL3949897 | — | — | 1 | 8.46 |
| CHEMBL3927591 | — | — | 1 | 8.46 |
| CHEMBL3922869 | — | — | 1 | 8.42 |
| CHEMBL3960796 | — | — | 1 | 8.41 |
| CHEMBL3986495 | — | — | 1 | 8.36 |
| CHEMBL3949157 | — | — | 1 | 8.26 |
| CHEMBL4639325 | — | — | 1 | 8.25 |
| CHEMBL3955209 | — | — | 1 | 8.25 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4641600 | — | EC50 | = | 0.8 | nM | 9.10 |
| CHEMBL4645241 | — | EC50 | = | 1.1 | nM | 8.96 |
| CHEMBL4644026 | — | EC50 | = | 1.1 | nM | 8.96 |
| CHEMBL3961836 | — | EC50 | = | 1.1 | nM | 8.96 |
| CHEMBL3955887 | — | EC50 | = | 1.3 | nM | 8.89 |
| CHEMBL4643882 | — | EC50 | = | 1.5 | nM | 8.82 |
| CHEMBL3925436 | — | EC50 | = | 1.6 | nM | 8.80 |
| CHEMBL3961240 | — | EC50 | = | 1.6 | nM | 8.80 |
| CHEMBL3931672 | MK-8876 | EC50 | = | 2.2 | nM | 8.66 |
| CHEMBL3930991 | — | EC50 | = | 2.4 | nM | 8.62 |
| CHEMBL4115427 | — | EC50 | = | 2.6 | nM | 8.59 |
| CHEMBL4648683 | — | EC50 | = | 2.6 | nM | 8.59 |
| CHEMBL3964459 | — | EC50 | = | 2.7 | nM | 8.57 |
| CHEMBL3942127 | — | EC50 | = | 2.7 | nM | 8.57 |
| CHEMBL3958500 | — | EC50 | = | 2.8 | nM | 8.55 |
| CHEMBL4636179 | — | EC50 | = | 2.9 | nM | 8.54 |
| CHEMBL3978278 | — | EC50 | = | 3.3 | nM | 8.48 |
| CHEMBL3949897 | — | EC50 | = | 3.5 | nM | 8.46 |
| CHEMBL3927591 | — | EC50 | = | 3.5 | nM | 8.46 |
| CHEMBL3922869 | — | EC50 | = | 3.8 | nM | 8.42 |
| CHEMBL3960796 | — | EC50 | = | 3.9 | nM | 8.41 |
| CHEMBL3986495 | — | EC50 | = | 4.4 | nM | 8.36 |
| CHEMBL3949157 | — | EC50 | = | 5.5 | nM | 8.26 |
| CHEMBL4639325 | — | EC50 | = | 5.6 | nM | 8.25 |
| CHEMBL3955209 | — | EC50 | = | 5.6 | nM | 8.25 |