Assay Detail
Binding
CHEMBL4628145
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Non-nucleoside inhibition of NS5B polymerase C316Y mutant in HCV genotype 1a by Taqman probe based RT-PCR analysis
25
Total Activities
25
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Hepatitis C virus subtype 1a |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Target
RNA-directed RNA polymerase (CHEMBL4296320) ↗| Type | SINGLE PROTEIN |
| Organism | Hepacivirus hominis |
Publication
Multi-step parallel synthesis enabled optimization of benzofuran derivatives as pan-genotypic non-nucleoside inhibitors of HCV NS5B.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 25 | 7.68 | 8.64 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3931672 | MK-8876 | 1.0 | 1 | 8.64 |
| CHEMBL3961836 | — | — | 1 | 8.54 |
| CHEMBL3955887 | — | — | 1 | 8.46 |
| CHEMBL3930991 | — | — | 1 | 8.39 |
| CHEMBL3961240 | — | — | 1 | 8.34 |
| CHEMBL4641600 | — | — | 1 | 8.27 |
| CHEMBL3942127 | — | — | 1 | 8.25 |
| CHEMBL3986495 | — | — | 1 | 8.21 |
| CHEMBL3960796 | — | — | 1 | 7.93 |
| CHEMBL3949157 | — | — | 1 | 7.92 |
| CHEMBL4636179 | — | — | 1 | 7.81 |
| CHEMBL4115427 | — | — | 1 | 7.75 |
| CHEMBL4644026 | — | — | 1 | 7.68 |
| CHEMBL3978278 | — | — | 1 | 7.53 |
| CHEMBL3964459 | — | — | 1 | 7.53 |
| CHEMBL4645241 | — | — | 1 | 7.52 |
| CHEMBL3958500 | — | — | 1 | 7.49 |
| CHEMBL3925436 | — | — | 1 | 7.45 |
| CHEMBL4648683 | — | — | 1 | 7.45 |
| CHEMBL4643882 | — | — | 1 | 7.36 |
| CHEMBL3927591 | — | — | 1 | 7.17 |
| CHEMBL3949897 | — | — | 1 | 7.16 |
| CHEMBL3955209 | — | — | 1 | 6.53 |
| CHEMBL3922869 | — | — | 1 | 6.34 |
| CHEMBL4639325 | — | — | 1 | 6.28 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3931672 | MK-8876 | EC50 | = | 2.3 | nM | 8.64 |
| CHEMBL3961836 | — | EC50 | = | 2.9 | nM | 8.54 |
| CHEMBL3955887 | — | EC50 | = | 3.5 | nM | 8.46 |
| CHEMBL3930991 | — | EC50 | = | 4.1 | nM | 8.39 |
| CHEMBL3961240 | — | EC50 | = | 4.6 | nM | 8.34 |
| CHEMBL4641600 | — | EC50 | = | 5.4 | nM | 8.27 |
| CHEMBL3942127 | — | EC50 | = | 5.6 | nM | 8.25 |
| CHEMBL3986495 | — | EC50 | = | 6.2 | nM | 8.21 |
| CHEMBL3960796 | — | EC50 | = | 11.8 | nM | 7.93 |
| CHEMBL3949157 | — | EC50 | = | 12.1 | nM | 7.92 |
| CHEMBL4636179 | — | EC50 | = | 15.4 | nM | 7.81 |
| CHEMBL4115427 | — | EC50 | = | 17.7 | nM | 7.75 |
| CHEMBL4644026 | — | EC50 | = | 21.0 | nM | 7.68 |
| CHEMBL3978278 | — | EC50 | = | 29.4 | nM | 7.53 |
| CHEMBL3964459 | — | EC50 | = | 29.3 | nM | 7.53 |
| CHEMBL4645241 | — | EC50 | = | 30.4 | nM | 7.52 |
| CHEMBL3958500 | — | EC50 | = | 32.2 | nM | 7.49 |
| CHEMBL3925436 | — | EC50 | = | 35.5 | nM | 7.45 |
| CHEMBL4648683 | — | EC50 | = | 35.8 | nM | 7.45 |
| CHEMBL4643882 | — | EC50 | = | 44.0 | nM | 7.36 |
| CHEMBL3927591 | — | EC50 | = | 67.8 | nM | 7.17 |
| CHEMBL3949897 | — | EC50 | = | 69.8 | nM | 7.16 |
| CHEMBL3955209 | — | EC50 | = | 292.4 | nM | 6.53 |
| CHEMBL3922869 | — | EC50 | = | 452.0 | nM | 6.34 |
| CHEMBL4639325 | — | EC50 | = | 522.5 | nM | 6.28 |