Assay Detail
Binding
CHEMBL4628146
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Non-nucleoside inhibition of NS5B polymerase S365A mutant in HCV genotype 1a by Taqman probe based RT-PCR analysis
25
Total Activities
25
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Hepatitis C virus subtype 1a |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Target
RNA-directed RNA polymerase (CHEMBL4296320) ↗| Type | SINGLE PROTEIN |
| Organism | Hepacivirus hominis |
Publication
Multi-step parallel synthesis enabled optimization of benzofuran derivatives as pan-genotypic non-nucleoside inhibitors of HCV NS5B.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 25 | 7.26 | 9.15 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3955887 | — | — | 1 | 9.15 |
| CHEMBL3931672 | MK-8876 | 1.0 | 1 | 9.00 |
| CHEMBL3961836 | — | — | 1 | 8.15 |
| CHEMBL3958500 | — | — | 1 | 8.08 |
| CHEMBL4641600 | — | — | 1 | 7.97 |
| CHEMBL3961240 | — | — | 1 | 7.91 |
| CHEMBL3986495 | — | — | 1 | 7.79 |
| CHEMBL4645241 | — | — | 1 | 7.76 |
| CHEMBL3930991 | — | — | 1 | 7.72 |
| CHEMBL4644026 | — | — | 1 | 7.44 |
| CHEMBL3949157 | — | — | 1 | 7.38 |
| CHEMBL3942127 | — | — | 1 | 7.33 |
| CHEMBL4115427 | — | — | 1 | 7.17 |
| CHEMBL3960796 | — | — | 1 | 7.12 |
| CHEMBL3978278 | — | — | 1 | 6.92 |
| CHEMBL3925436 | — | — | 1 | 6.86 |
| CHEMBL4643882 | — | — | 1 | 6.75 |
| CHEMBL3949897 | — | — | 1 | 6.72 |
| CHEMBL4648683 | — | — | 1 | 6.64 |
| CHEMBL4636179 | — | — | 1 | 6.56 |
| CHEMBL3927591 | — | — | 1 | 6.47 |
| CHEMBL3964459 | — | — | 1 | 6.35 |
| CHEMBL3955209 | — | — | 1 | 6.33 |
| CHEMBL4639325 | — | — | 1 | 5.95 |
| CHEMBL3922869 | — | — | 1 | 5.87 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3955887 | — | EC50 | = | 0.7 | nM | 9.15 |
| CHEMBL3931672 | MK-8876 | EC50 | = | 1.0 | nM | 9.00 |
| CHEMBL3961836 | — | EC50 | = | 7.1 | nM | 8.15 |
| CHEMBL3958500 | — | EC50 | = | 8.3 | nM | 8.08 |
| CHEMBL4641600 | — | EC50 | = | 10.6 | nM | 7.97 |
| CHEMBL3961240 | — | EC50 | = | 12.3 | nM | 7.91 |
| CHEMBL3986495 | — | EC50 | = | 16.3 | nM | 7.79 |
| CHEMBL4645241 | — | EC50 | = | 17.3 | nM | 7.76 |
| CHEMBL3930991 | — | EC50 | = | 19.1 | nM | 7.72 |
| CHEMBL4644026 | — | EC50 | = | 36.6 | nM | 7.44 |
| CHEMBL3949157 | — | EC50 | = | 41.9 | nM | 7.38 |
| CHEMBL3942127 | — | EC50 | = | 46.7 | nM | 7.33 |
| CHEMBL4115427 | — | EC50 | = | 68.0 | nM | 7.17 |
| CHEMBL3960796 | — | EC50 | = | 76.4 | nM | 7.12 |
| CHEMBL3978278 | — | EC50 | = | 120.3 | nM | 6.92 |
| CHEMBL3925436 | — | EC50 | = | 136.8 | nM | 6.86 |
| CHEMBL4643882 | — | EC50 | = | 177.0 | nM | 6.75 |
| CHEMBL3949897 | — | EC50 | = | 190.4 | nM | 6.72 |
| CHEMBL4648683 | — | EC50 | = | 227.9 | nM | 6.64 |
| CHEMBL4636179 | — | EC50 | = | 277.3 | nM | 6.56 |
| CHEMBL3927591 | — | EC50 | = | 334.9 | nM | 6.47 |
| CHEMBL3964459 | — | EC50 | = | 445.6 | nM | 6.35 |
| CHEMBL3955209 | — | EC50 | = | 473.5 | nM | 6.33 |
| CHEMBL4639325 | — | EC50 | = | 1131.0 | nM | 5.95 |
| CHEMBL3922869 | — | EC50 | = | 1356.0 | nM | 5.87 |