Assay Detail
Binding
CHEMBL4628286
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Inhibition of IDO1 (unknown origin) assessed as reduction in kynurenine formation using L-tryptophan as substrate incubated for 60 mins by fluorescence based assay
20
Total Activities
20
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Discovery of novel hydroxyamidine derivatives as indoleamine 2,3-dioxygenase 1 inhibitors with in vivo anti-tumor efficacy.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 20 | 6.86 | 7.18 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3545369 | EPACADOSTAT | 3.0 | 1 | 7.18 |
| CHEMBL4641167 | — | — | 1 | 7.16 |
| CHEMBL4644903 | — | — | 1 | 7.15 |
| CHEMBL4637369 | — | — | 1 | 7.06 |
| CHEMBL4644666 | — | — | 1 | 7.02 |
| CHEMBL4642406 | — | — | 1 | 7.01 |
| CHEMBL4645599 | — | — | 1 | 7.00 |
| CHEMBL4645780 | — | — | 1 | 6.98 |
| CHEMBL4639397 | — | — | 1 | 6.97 |
| CHEMBL4639448 | — | — | 1 | 6.90 |
| CHEMBL4645531 | — | — | 1 | 6.90 |
| CHEMBL4633901 | — | — | 1 | 6.87 |
| CHEMBL4643034 | — | — | 1 | 6.85 |
| CHEMBL4633995 | — | — | 1 | 6.72 |
| CHEMBL4639516 | — | — | 1 | 6.68 |
| CHEMBL4648971 | — | — | 1 | 6.67 |
| CHEMBL4646789 | — | — | 1 | 6.66 |
| CHEMBL4646976 | — | — | 1 | 6.66 |
| CHEMBL4646028 | — | — | 1 | 6.51 |
| CHEMBL4635808 | — | — | 1 | 6.21 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3545369 | EPACADOSTAT | IC50 | = | 66.0 | nM | 7.18 |
| CHEMBL4641167 | — | IC50 | = | 69.0 | nM | 7.16 |
| CHEMBL4644903 | — | IC50 | = | 71.0 | nM | 7.15 |
| CHEMBL4637369 | — | IC50 | = | 87.0 | nM | 7.06 |
| CHEMBL4644666 | — | IC50 | = | 95.0 | nM | 7.02 |
| CHEMBL4642406 | — | IC50 | = | 97.0 | nM | 7.01 |
| CHEMBL4645599 | — | IC50 | = | 99.0 | nM | 7.00 |
| CHEMBL4645780 | — | IC50 | = | 105.0 | nM | 6.98 |
| CHEMBL4639397 | — | IC50 | = | 108.0 | nM | 6.97 |
| CHEMBL4639448 | — | IC50 | = | 126.0 | nM | 6.90 |
| CHEMBL4645531 | — | IC50 | = | 126.0 | nM | 6.90 |
| CHEMBL4633901 | — | IC50 | = | 135.0 | nM | 6.87 |
| CHEMBL4643034 | — | IC50 | = | 140.0 | nM | 6.85 |
| CHEMBL4633995 | — | IC50 | = | 191.0 | nM | 6.72 |
| CHEMBL4639516 | — | IC50 | = | 208.0 | nM | 6.68 |
| CHEMBL4648971 | — | IC50 | = | 212.0 | nM | 6.67 |
| CHEMBL4646789 | — | IC50 | = | 218.0 | nM | 6.66 |
| CHEMBL4646976 | — | IC50 | = | 218.0 | nM | 6.66 |
| CHEMBL4646028 | — | IC50 | = | 312.0 | nM | 6.51 |
| CHEMBL4635808 | — | IC50 | = | 609.0 | nM | 6.21 |