Assay Detail
Binding
CHEMBL4628287
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of IDO1 in IFN-gamma stimulated human HeLa cells assessed as reduction in kynurenine formation using L-tryptophan as substrate incubated for 24 hrs by UV-spectrophotometry
20
Total Activities
20
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | HeLa |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Discovery of novel hydroxyamidine derivatives as indoleamine 2,3-dioxygenase 1 inhibitors with in vivo anti-tumor efficacy.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 20 | 7.28 | 8.10 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3545369 | EPACADOSTAT | 3.0 | 1 | 8.10 |
| CHEMBL4644903 | — | — | 1 | 7.96 |
| CHEMBL4639448 | — | — | 1 | 7.82 |
| CHEMBL4645780 | — | — | 1 | 7.77 |
| CHEMBL4642406 | — | — | 1 | 7.70 |
| CHEMBL4637369 | — | — | 1 | 7.57 |
| CHEMBL4646789 | — | — | 1 | 7.48 |
| CHEMBL4644666 | — | — | 1 | 7.39 |
| CHEMBL4639516 | — | — | 1 | 7.28 |
| CHEMBL4645599 | — | — | 1 | 7.23 |
| CHEMBL4641167 | — | — | 1 | 7.14 |
| CHEMBL4648971 | — | — | 1 | 7.10 |
| CHEMBL4646976 | — | — | 1 | 7.00 |
| CHEMBL4633995 | — | — | 1 | 6.84 |
| CHEMBL4643034 | — | — | 1 | 6.57 |
| CHEMBL4646028 | — | — | 1 | 6.57 |
| CHEMBL4639397 | — | — | 1 | 6.25 |
| CHEMBL4635808 | — | — | 1 | - |
| CHEMBL4633901 | — | — | 1 | - |
| CHEMBL4645531 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3545369 | EPACADOSTAT | EC50 | = | 8.0 | nM | 8.10 |
| CHEMBL4644903 | — | EC50 | = | 11.0 | nM | 7.96 |
| CHEMBL4639448 | — | EC50 | = | 15.0 | nM | 7.82 |
| CHEMBL4645780 | — | EC50 | = | 17.0 | nM | 7.77 |
| CHEMBL4642406 | — | EC50 | = | 20.0 | nM | 7.70 |
| CHEMBL4637369 | — | EC50 | = | 27.0 | nM | 7.57 |
| CHEMBL4646789 | — | EC50 | = | 33.0 | nM | 7.48 |
| CHEMBL4644666 | — | EC50 | = | 41.0 | nM | 7.39 |
| CHEMBL4639516 | — | EC50 | = | 53.0 | nM | 7.28 |
| CHEMBL4645599 | — | EC50 | = | 59.0 | nM | 7.23 |
| CHEMBL4641167 | — | EC50 | = | 73.0 | nM | 7.14 |
| CHEMBL4648971 | — | EC50 | = | 79.0 | nM | 7.10 |
| CHEMBL4646976 | — | EC50 | = | 101.0 | nM | 7.00 |
| CHEMBL4633995 | — | EC50 | = | 143.0 | nM | 6.84 |
| CHEMBL4643034 | — | EC50 | = | 268.0 | nM | 6.57 |
| CHEMBL4646028 | — | EC50 | = | 268.0 | nM | 6.57 |
| CHEMBL4639397 | — | EC50 | = | 556.0 | nM | 6.25 |
| CHEMBL4635808 | — | EC50 | > | 800.0 | nM | - |
| CHEMBL4633901 | — | EC50 | > | 800.0 | nM | - |
| CHEMBL4645531 | — | EC50 | > | 800.0 | nM | - |