Assay Detail
Binding
CHEMBL4628292
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Inhibition of HDAC1 (unknown origin)
15
Total Activities
15
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Design, synthesis and anticancer activities of novel dual poly(ADP-ribose) polymerase-1/histone deacetylase-1 inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 15 | 6.27 | 6.85 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4639901 | — | — | 1 | 6.85 |
| CHEMBL4087968 | — | — | 1 | 6.80 |
| CHEMBL4636062 | — | — | 1 | 6.47 |
| CHEMBL4645040 | — | — | 1 | 6.47 |
| CHEMBL4635787 | — | — | 1 | 6.47 |
| CHEMBL4635211 | — | — | 1 | 6.28 |
| CHEMBL4646474 | — | — | 1 | 6.13 |
| CHEMBL4633915 | — | — | 1 | 6.09 |
| CHEMBL4639985 | — | — | 1 | 6.09 |
| CHEMBL4638228 | — | — | 1 | 6.05 |
| CHEMBL4645204 | — | — | 1 | 6.04 |
| CHEMBL4637848 | — | — | 1 | 6.03 |
| CHEMBL4642383 | — | — | 1 | 6.02 |
| CHEMBL4639703 | — | — | 1 | 6.00 |
| CHEMBL521686 | OLAPARIB | 4.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4639901 | — | IC50 | = | 140.0 | nM | 6.85 |
| CHEMBL4087968 | — | IC50 | = | 160.0 | nM | 6.80 |
| CHEMBL4636062 | — | IC50 | = | 340.0 | nM | 6.47 |
| CHEMBL4645040 | — | IC50 | = | 340.0 | nM | 6.47 |
| CHEMBL4635787 | — | IC50 | = | 340.0 | nM | 6.47 |
| CHEMBL4635211 | — | IC50 | = | 520.0 | nM | 6.28 |
| CHEMBL4646474 | — | IC50 | = | 740.0 | nM | 6.13 |
| CHEMBL4633915 | — | IC50 | = | 810.0 | nM | 6.09 |
| CHEMBL4639985 | — | IC50 | = | 820.0 | nM | 6.09 |
| CHEMBL4638228 | — | IC50 | = | 890.0 | nM | 6.05 |
| CHEMBL4645204 | — | IC50 | = | 910.0 | nM | 6.04 |
| CHEMBL4637848 | — | IC50 | = | 940.0 | nM | 6.03 |
| CHEMBL4642383 | — | IC50 | = | 950.0 | nM | 6.02 |
| CHEMBL4639703 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL521686 | OLAPARIB | IC50 | - | — | - |