Assay Detail
Binding
CHEMBL4628301
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of recombinant human MAOB expressed in baculovirus infected in BTI cells using kynuramine as substrate after 30 mins by fluorescence based assay
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Design, synthesis and evaluation of flurbiprofen-clioquinol hybrids as multitarget-directed ligands against Alzheimer's disease.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 9 | 5.51 | 7.94 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL887 | RASAGILINE | 4.0 | 1 | 7.94 |
| CHEMBL8706 | CLORGILINE | 2.0 | 1 | 5.63 |
| CHEMBL92401 | IPRONIAZID | 2.0 | 1 | 5.63 |
| CHEMBL4647293 | — | — | 1 | 4.99 |
| CHEMBL4636637 | — | — | 1 | 4.82 |
| CHEMBL4643921 | — | — | 1 | 4.79 |
| CHEMBL4648532 | — | — | 1 | 4.78 |
| CHEMBL563 | FLURBIPROFEN | 4.0 | 1 | - |
| CHEMBL497 | CLIOQUINOL | 4.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL887 | RASAGILINE | IC50 | = | 11.6 | nM | 7.94 |
| CHEMBL8706 | CLORGILINE | IC50 | = | 2340.0 | nM | 5.63 |
| CHEMBL92401 | IPRONIAZID | IC50 | = | 2340.0 | nM | 5.63 |
| CHEMBL4647293 | — | IC50 | = | 10300.0 | nM | 4.99 |
| CHEMBL4636637 | — | IC50 | = | 15100.0 | nM | 4.82 |
| CHEMBL4643921 | — | IC50 | = | 16300.0 | nM | 4.79 |
| CHEMBL4648532 | — | IC50 | = | 16600.0 | nM | 4.78 |
| CHEMBL563 | FLURBIPROFEN | IC50 | - | — | - | |
| CHEMBL497 | CLIOQUINOL | IC50 | - | — | - |